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- W97710725 abstract "Publisher Summary This chapter discusses the hormonal actions of Vitamin D. Vitamin D exerts its biological effects after metabolism to more polar daughter metabolites that generate their biological responses by interaction with the genome to induce the biosynthesis of specific proteins essential for the biological response. The secosteroid structure of vitamin D emphasizes the similarity with that of the classical steroid hormones. Recognition of the metabolism of vitamin D3to biologically active daughter metabolites was an important step forward in understanding the mode of action of vitamin D. The most biologically active form of vitamin D3is 1, 25-dihydroxyvitamin D3(l, 25(OH)2D3). After entering the body as a vitamin or as a hormone, vitamin D3undergoes a series of metabolic transformations before interaction with specific receptors and induction of the genome in the target tissues to generate its biological responses. Vitamin D3functions as a prohormone to its most active metabolite, l, 25(OH)2D3. The kidney acts as an endocrine gland for the site of production and secretion of l, 25(OH)2D3. This metabolite/hormone is then transported through the bloodstream to its target tissues, particularly intestine and bone, where it interacts with the genome to produce its characteristic biological responses of increasing intestinal-calcium absorption and bone -calcium mobilization." @default.
- W97710725 created "2016-06-24" @default.
- W97710725 creator A5034584507 @default.
- W97710725 date "1984-01-01" @default.
- W97710725 modified "2023-09-26" @default.
- W97710725 title "Hormonal Actions of Vitamin D" @default.
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- W97710725 doi "https://doi.org/10.1016/b978-0-12-152824-9.50012-5" @default.
- W97710725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6094111" @default.
- W97710725 hasPublicationYear "1984" @default.
- W97710725 type Work @default.