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- W977234105 abstract "Publisher Summary The receptors constituting the site of action of 5-HT are called tryptamine receptors. On the guinea pig ileum, excess of tryptamine abolishes the response to both tryptamine and 5-HT, and excess of 5-HT does precisely the same; both compounds appear therefore to act at the same site. In the brain, physiological effects are produced by tryptamine, 5-HT, and many other derivatives of tryptamine. It is usually assumed that all these compounds act at the same site, though the type of action produced may be quite different. The difference may be because of different configurations of the reaction product between receptor and drugs, or to the existence of more than one type of tryptamine receptor with different affinities for each compound. In peripheral organs, the susceptibility of the tryptamine receptors to antagonists varies greatly—the receptors in the rat stomach, such as those of the rat uterus, the cat nictitating membrane, or the guinea pig bronchi, are easily inhibited by lysergic acid diethylamide (LSD) but not by morphine." @default.
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- W977234105 date "1968-01-01" @default.
- W977234105 modified "2023-09-27" @default.
- W977234105 title "Cerebral Tryptamine Receptors: Functional Considerations" @default.
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- W977234105 doi "https://doi.org/10.1016/s1054-3589(08)60291-4" @default.
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