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- W977248766 abstract "Immunoisolation is a means of implementing cell transplantation using selectively permeable membranes to isolate the cells from the host's immune system. The encapsulated cells, from either the same species (allogeneic) or a different species (xenogeneic), produce the desired therapeutic product, while the membrane prevents their rejection. Cells of primary (for example, islets of Langerhans), immortalized (for example, pheochromocytoma, and PC12 cells), or engineered (for example, baby hamster kidney, BHK, cells engineered to produce nerve growth factor, and NGF) origins can be used in immunoisolation devices because the membrane protects the cells against an immune attack. Immunoisolation devices, such as for the treatment of insulin-dependent diabetes, must provide for the appropriate behavior of an adequate cell mass for extended periods. This requires control of device size and shape, membrane permeability and permselectivity, and intracapsule environment and device “biocompatibility.” The importance of the principles underlying the mass transport limitations to immunoisolation devices and especially microencapsulated cell size, the role of the internal capsule environment on immunoisolated cell behavior, and the consequences of implantation has also been highlighted." @default.
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- W977248766 date "1998-01-01" @default.
- W977248766 modified "2023-09-23" @default.
- W977248766 title "Immunoisolation" @default.
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- W977248766 doi "https://doi.org/10.1016/b978-008042689-1/50016-9" @default.
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