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• W977371401 abstract "Leskinen, Tuija Long-term leisure-time physical activity vs. inactivity, physical fitness, body composition and metabolic health characteristics: a co-twin control study Jyvaskyla: University of Jyvaskyla, 2013, 99 p. (Studies in Sport, Physical education and health ISSN 0356-1070; 194) ISBN 978-951-39-5208-2 (nid.) ISBN 978-951-39-5209-9 (PDF) Finnish summary Diss. If an individual is physically active or inactive, then this may have a major impact on health and disease development. In this thesis, the associations between longterm leisure-time physical activity vs. inactivity and health outcomes were studied among 16 middle-aged and older twin pairs (7 were monozygotic pairs who share all of their genes at the sequence level) with a persistent discordance in their leisure-time physical activity habits. At the end of the follow-up, clinical exercise test with cycle ergometer, maximal isometric knee extensor force, and body composition were assessed. Visceral fat area, liver fat score and thigh composition were measured using MRI. The results revealed that the physically active twins had 23% higher VO2peak values than their inactive co-twins but also 20% higher knee extensor forces although no further significant intrapair differences in skeletal muscle properties were found. The follow-up weight gain was attenuated among the physically active twins but there was no significant intrapair difference in body weight at the end of the follow-up (p=0.12). However, the inactive twins had significantly more body fat, 1.5 times more visceral and midthigh intramuscular (extramyocellular) fat and a higher liver fat score compared to their active co-twins. The intrapair difference in the level of ectopic fat was also significant among monozygotic cotwins. To further understand the underlying mechanisms, biopsies were taken from m. vastus lateralis and abdominal subcutaneous adipose tissue from 10 volunteer pairs for the gene expression analysis. Gene Set Enrichment Analysis revealed up-regulated metabolic pathways (such as oxidative phosphorylation and valine, leucine and isoleucine degradation) among the active compared to the inactive twins. The expression centroids of these gene sets were associated with cardio-metabolic risk factors, including fitness. In conclusion, long-term leisure-time physical activity is associated with a better physical fitness and in particular with a lowered rate of ectopic fat accumulation. Therefore regular long-term leisure-time physical activity may confer a major benefit in combatting the appearance of cardio-metabolic disease." @default.
• W977371401 created "2016-06-24" @default.
• W977371401 creator A5011167290 @default.
• W977371401 date "2013-01-01" @default.
• W977371401 modified "2023-09-27" @default.
• W977371401 title "Long-term leisure-time physical activity vs. inactivity, physical fitness, body composition and metabolic health characteristics : a co-twin control study" @default.
• W977371401 cites W1507267913 @default.
• W977371401 cites W1559843211 @default.
• W977371401 cites W1588516858 @default.
• W977371401 cites W1588636472 @default.
• W977371401 cites W1924084714 @default.
• W977371401 cites W1933285363 @default.
• W977371401 cites W1964169171 @default.
• W977371401 cites W1964434833 @default.
• W977371401 cites W1980681837 @default.
• W977371401 cites W1981831271 @default.
• W977371401 cites W1982488301 @default.
• W977371401 cites W1982575947 @default.
• W977371401 cites W1983726739 @default.
• W977371401 cites W1987588766 @default.
• W977371401 cites W1988089886 @default.
• W977371401 cites W1988270878 @default.
• W977371401 cites W1988907383 @default.
• W977371401 cites W1991334358 @default.
• W977371401 cites W1991821391 @default.
• W977371401 cites W2003336167 @default.
• W977371401 cites W2004916577 @default.
• W977371401 cites W2006417958 @default.
• W977371401 cites W2009817646 @default.
• W977371401 cites W2012698118 @default.
• W977371401 cites W2016273082 @default.
• W977371401 cites W2016420804 @default.
• W977371401 cites W2016624754 @default.
• W977371401 cites W2016785044 @default.
• W977371401 cites W2016921793 @default.
• W977371401 cites W2017565112 @default.
• W977371401 cites W2018773970 @default.
• W977371401 cites W2022138763 @default.
• W977371401 cites W2023294484 @default.
• W977371401 cites W2024256895 @default.
• W977371401 cites W2027764283 @default.
• W977371401 cites W2028441056 @default.
• W977371401 cites W2028964297 @default.
• W977371401 cites W2029932732 @default.
• W977371401 cites W2029957148 @default.
• W977371401 cites W2032173003 @default.
• W977371401 cites W2035108129 @default.
• W977371401 cites W2041966182 @default.
• W977371401 cites W2043568183 @default.
• W977371401 cites W2047307326 @default.
• W977371401 cites W2047622104 @default.
• W977371401 cites W2053265995 @default.
• W977371401 cites W2055350029 @default.
• W977371401 cites W2057643886 @default.
• W977371401 cites W2060502922 @default.
• W977371401 cites W2064468329 @default.
• W977371401 cites W2066813035 @default.
• W977371401 cites W2067508138 @default.
• W977371401 cites W2067813974 @default.
• W977371401 cites W2070009406 @default.
• W977371401 cites W2070426618 @default.
• W977371401 cites W2070559035 @default.
• W977371401 cites W2072989023 @default.
• W977371401 cites W2073241391 @default.
• W977371401 cites W2073817282 @default.
• W977371401 cites W2081573697 @default.
• W977371401 cites W2083350111 @default.
• W977371401 cites W2083958242 @default.
• W977371401 cites W2089825058 @default.
• W977371401 cites W2094564248 @default.
• W977371401 cites W2094757291 @default.
• W977371401 cites W2096436012 @default.
• W977371401 cites W2097121315 @default.
• W977371401 cites W2097556952 @default.
• W977371401 cites W2098707930 @default.
• W977371401 cites W2099281324 @default.
• W977371401 cites W2099786709 @default.
• W977371401 cites W2100703140 @default.
• W977371401 cites W2102452049 @default.
• W977371401 cites W2104745222 @default.
• W977371401 cites W2105381419 @default.
• W977371401 cites W2106650290 @default.
• W977371401 cites W2107150305 @default.
• W977371401 cites W2107338033 @default.
• W977371401 cites W2107417361 @default.
• W977371401 cites W2107539051 @default.
• W977371401 cites W2107886081 @default.
• W977371401 cites W2109469243 @default.
• W977371401 cites W2110141259 @default.
• W977371401 cites W2110957605 @default.
• W977371401 cites W2111589767 @default.
• W977371401 cites W2112040893 @default.
• W977371401 cites W2114467602 @default.
• W977371401 cites W2114754207 @default.
• W977371401 cites W2116634113 @default.
• W977371401 cites W2119453708 @default.
• W977371401 cites W2120031015 @default.
• W977371401 cites W2122367003 @default.
• W977371401 cites W2122611471 @default.
• W977371401 cites W2123106337 @default.

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