Matches in SemOpenAlex for { <https://semopenalex.org/work/W97737902> ?p ?o ?g. }
- W97737902 abstract "Solar UV radiation is one of the most abundant carcinogens in our natural environment. Despite its strong genotoxicity, skin cancers develop only late in life in a minority of fair-skinned Caucasians, attesting to the skin’s excellent adaptation. Although epidemiologic studies on skin cancer in the general population clearly incriminate sun exposure as an important etiologic factor, these studies provide little or no information on underlying mechanisms. The discovery that the dramatically increased skin cancer risk in xeroderma pigmentosum (XP) patients is related to their defective repair of UV-induced DNA damage has greatly advanced our understanding of UV carcinogenesis. This rare syndrome revealed both the importance of DNA repair and the strong carcinogenic challenge from ambient UV radiation. Although molecular analyses of skin cancers have identified key somatic changes in various genes, it remains largely obscure whether and how and to what extent UV radiation has caused these changes, with the notable exception of mutations in the p53 tumor suppressor genes from skin carcinomas, which show a clear UV signature." @default.
- W97737902 created "2016-06-24" @default.
- W97737902 creator A5013793536 @default.
- W97737902 creator A5019483239 @default.
- W97737902 date "2010-01-01" @default.
- W97737902 modified "2023-09-23" @default.
- W97737902 title "Ultraviolet Radiation as a Carcinogen*" @default.
- W97737902 cites W1484882395 @default.
- W97737902 cites W1488470386 @default.
- W97737902 cites W1535532537 @default.
- W97737902 cites W1542869389 @default.
- W97737902 cites W1545831902 @default.
- W97737902 cites W1546991696 @default.
- W97737902 cites W1549810746 @default.
- W97737902 cites W1552426876 @default.
- W97737902 cites W1567779734 @default.
- W97737902 cites W1581466567 @default.
- W97737902 cites W1584117869 @default.
- W97737902 cites W158760893 @default.
- W97737902 cites W1599137086 @default.
- W97737902 cites W1676048097 @default.
- W97737902 cites W1785791360 @default.
- W97737902 cites W17999883 @default.
- W97737902 cites W1911896122 @default.
- W97737902 cites W1916022022 @default.
- W97737902 cites W1935496836 @default.
- W97737902 cites W1939830750 @default.
- W97737902 cites W1946062417 @default.
- W97737902 cites W1965175223 @default.
- W97737902 cites W1967629365 @default.
- W97737902 cites W1969190950 @default.
- W97737902 cites W1969853783 @default.
- W97737902 cites W1970195561 @default.
- W97737902 cites W1970566518 @default.
- W97737902 cites W1972834320 @default.
- W97737902 cites W1975315379 @default.
- W97737902 cites W1976316208 @default.
- W97737902 cites W1977982042 @default.
- W97737902 cites W1979627083 @default.
- W97737902 cites W1980591242 @default.
- W97737902 cites W1982232706 @default.
- W97737902 cites W1984128578 @default.
- W97737902 cites W1984919526 @default.
- W97737902 cites W1987560013 @default.
- W97737902 cites W1989689964 @default.
- W97737902 cites W1991633189 @default.
- W97737902 cites W1992313923 @default.
- W97737902 cites W1992668722 @default.
- W97737902 cites W1992835723 @default.
- W97737902 cites W1993358791 @default.
- W97737902 cites W1995535123 @default.
- W97737902 cites W2000054009 @default.
- W97737902 cites W2000547083 @default.
- W97737902 cites W2001155940 @default.
- W97737902 cites W2005344674 @default.
- W97737902 cites W2005817830 @default.
- W97737902 cites W2006247681 @default.
- W97737902 cites W2007361178 @default.
- W97737902 cites W2008512283 @default.
- W97737902 cites W2012929907 @default.
- W97737902 cites W2013706403 @default.
- W97737902 cites W2014100758 @default.
- W97737902 cites W2014615159 @default.
- W97737902 cites W2015252107 @default.
- W97737902 cites W2015966719 @default.
- W97737902 cites W2019544036 @default.
- W97737902 cites W2019590399 @default.
- W97737902 cites W2020133847 @default.
- W97737902 cites W2022566446 @default.
- W97737902 cites W2023097924 @default.
- W97737902 cites W2025174606 @default.
- W97737902 cites W2026282796 @default.
- W97737902 cites W2027538421 @default.
- W97737902 cites W2028494702 @default.
- W97737902 cites W2028528554 @default.
- W97737902 cites W2028752124 @default.
- W97737902 cites W2030714377 @default.
- W97737902 cites W2031620785 @default.
- W97737902 cites W2032128602 @default.
- W97737902 cites W2032296088 @default.
- W97737902 cites W2034895153 @default.
- W97737902 cites W2038858817 @default.
- W97737902 cites W2040081487 @default.
- W97737902 cites W2041573530 @default.
- W97737902 cites W2041683774 @default.
- W97737902 cites W2041848980 @default.
- W97737902 cites W2043285825 @default.
- W97737902 cites W2043478990 @default.
- W97737902 cites W2043937188 @default.
- W97737902 cites W2046081435 @default.
- W97737902 cites W2046619774 @default.
- W97737902 cites W2047288052 @default.
- W97737902 cites W2048607797 @default.
- W97737902 cites W2049311151 @default.
- W97737902 cites W2050212509 @default.
- W97737902 cites W2050254846 @default.
- W97737902 cites W2050783603 @default.
- W97737902 cites W2052454337 @default.
- W97737902 cites W2053617035 @default.
- W97737902 cites W2054286843 @default.