Matches in SemOpenAlex for { <https://semopenalex.org/work/W97760204> ?p ?o ?g. }
- W97760204 endingPage "2515" @default.
- W97760204 startingPage "2507" @default.
- W97760204 abstract "A costimulatory signal from B7–1 (CD80) to its counter-receptor CD28 is required for T-cell activation. Many tumors, including most human leukemias, lack expression of B7–1, and this has been suggested to contribute to the failure of immune recognition of these diseases. A murine leukemia model system was developed to assess the potential role of B7–1 in the induction immunity to leukemia cells. The nonleukemic 32Dc13 myeloid cell line was transformed by transfection of the BCR/ABL gene, generating a subline (32Dp210/clone 26) that was leukemic and rapidly lethal to syngeneic, immunocompetent C3H/HeJ mice or T-cell-deficient nude mice. B7–1-modified leukemic cells remained lethal in nude mice, but caused only a transient, nonlethal leukemia in C3H/HeJ mice. After a single exposure to live, nonirradiated B7–1-modified leukemic cells, C3H/HeJ mice developed protective immunity against subsequent challenge with B7–1(-) leukemic cells. Further, hyperimmunization with B7–1(+) leukemic cells prolonged the survival of mice previously injected with a lethal number of B7–1(-) leukemic cells. These results indicate that myeloid leukemic cells may be attractive candidates for B7–1 gene transfer." @default.
- W97760204 created "2016-06-24" @default.
- W97760204 creator A5019128517 @default.
- W97760204 creator A5022220719 @default.
- W97760204 creator A5039503690 @default.
- W97760204 creator A5039536808 @default.
- W97760204 creator A5058249824 @default.
- W97760204 creator A5075310347 @default.
- W97760204 creator A5081619954 @default.
- W97760204 date "1995-05-01" @default.
- W97760204 modified "2023-10-17" @default.
- W97760204 title "Role of B7-1 in mediating an immune response to myeloid leukemia cells" @default.
- W97760204 cites W1543607558 @default.
- W97760204 cites W1575694343 @default.
- W97760204 cites W1586789350 @default.
- W97760204 cites W1608160351 @default.
- W97760204 cites W1819529703 @default.
- W97760204 cites W1826859465 @default.
- W97760204 cites W1908705759 @default.
- W97760204 cites W1946481417 @default.
- W97760204 cites W1972354503 @default.
- W97760204 cites W1976942018 @default.
- W97760204 cites W1978416272 @default.
- W97760204 cites W1990668606 @default.
- W97760204 cites W1991148746 @default.
- W97760204 cites W2002323372 @default.
- W97760204 cites W2005190251 @default.
- W97760204 cites W2007035782 @default.
- W97760204 cites W2007721356 @default.
- W97760204 cites W2009228522 @default.
- W97760204 cites W2012241435 @default.
- W97760204 cites W2013758383 @default.
- W97760204 cites W2028352245 @default.
- W97760204 cites W2037626742 @default.
- W97760204 cites W2039825042 @default.
- W97760204 cites W2062029576 @default.
- W97760204 cites W2071688202 @default.
- W97760204 cites W2076372887 @default.
- W97760204 cites W2076479500 @default.
- W97760204 cites W2082664733 @default.
- W97760204 cites W2084906660 @default.
- W97760204 cites W2087013294 @default.
- W97760204 cites W2087526889 @default.
- W97760204 cites W2091691801 @default.
- W97760204 cites W2092312916 @default.
- W97760204 cites W2103973613 @default.
- W97760204 cites W2134677648 @default.
- W97760204 cites W2136353300 @default.
- W97760204 cites W2149120449 @default.
- W97760204 cites W2159728393 @default.
- W97760204 cites W2166192944 @default.
- W97760204 cites W2470939476 @default.
- W97760204 cites W30097818 @default.
- W97760204 cites W30300769 @default.
- W97760204 doi "https://doi.org/10.1182/blood.v85.9.2507.bloodjournal8592507" @default.
- W97760204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7537118" @default.
- W97760204 hasPublicationYear "1995" @default.
- W97760204 type Work @default.
- W97760204 sameAs 97760204 @default.
- W97760204 citedByCount "120" @default.
- W97760204 countsByYear W977602042013 @default.
- W97760204 countsByYear W977602042015 @default.
- W97760204 countsByYear W977602042020 @default.
- W97760204 countsByYear W977602042022 @default.
- W97760204 crossrefType "journal-article" @default.
- W97760204 hasAuthorship W97760204A5019128517 @default.
- W97760204 hasAuthorship W97760204A5022220719 @default.
- W97760204 hasAuthorship W97760204A5039503690 @default.
- W97760204 hasAuthorship W97760204A5039536808 @default.
- W97760204 hasAuthorship W97760204A5058249824 @default.
- W97760204 hasAuthorship W97760204A5075310347 @default.
- W97760204 hasAuthorship W97760204A5081619954 @default.
- W97760204 hasBestOaLocation W977602041 @default.
- W97760204 hasConcept C104317684 @default.
- W97760204 hasConcept C126322002 @default.
- W97760204 hasConcept C154317977 @default.
- W97760204 hasConcept C202751555 @default.
- W97760204 hasConcept C203014093 @default.
- W97760204 hasConcept C2778297628 @default.
- W97760204 hasConcept C2778461978 @default.
- W97760204 hasConcept C2778729363 @default.
- W97760204 hasConcept C2779282312 @default.
- W97760204 hasConcept C2910058513 @default.
- W97760204 hasConcept C2911091166 @default.
- W97760204 hasConcept C39347974 @default.
- W97760204 hasConcept C502942594 @default.
- W97760204 hasConcept C55493867 @default.
- W97760204 hasConcept C71924100 @default.
- W97760204 hasConcept C81089528 @default.
- W97760204 hasConcept C86803240 @default.
- W97760204 hasConcept C8891405 @default.
- W97760204 hasConceptScore W97760204C104317684 @default.
- W97760204 hasConceptScore W97760204C126322002 @default.
- W97760204 hasConceptScore W97760204C154317977 @default.
- W97760204 hasConceptScore W97760204C202751555 @default.
- W97760204 hasConceptScore W97760204C203014093 @default.
- W97760204 hasConceptScore W97760204C2778297628 @default.
- W97760204 hasConceptScore W97760204C2778461978 @default.