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- W977728092 abstract "Ethinyl estradiol in doses therapeutically active in advanced breast cancer significantly increased basal prolactin secretion. Nafoxidine failed to stimulate prolactin secretion and had an inhibitory effect in one case. Nafoxidine is an estrogen antagonist operating as a competitive inhibitor of estrogen at tissue-specific estrogen receptors. It also has weak estrogenic actions in postmenopausal women. Nafoxidine has been found to induce remission in 35% of postmenopausal women with advanced breast cancer. Since both nafoxidine and ethinyl estradiol are active in this category of patients it is postulated that nafoxidines effect is a re- sult of its estrogen action rather than its estrogen antagonism." @default.
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- W977728092 date "1974-03-01" @default.
- W977728092 modified "2023-09-23" @default.
- W977728092 title "Breast cancer regression under estrogen therapy" @default.
- W977728092 hasPublicationYear "1974" @default.
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