FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W97797872> ?p ?o ?g. }

• W97797872 endingPage "41" @default.
• W97797872 startingPage "8532" @default.
• W97797872 abstract "Fibrous dysplasia (FD) as an abnormal bone growth is one of the common fibro-osseous leasions (FOL) in oral and maxillofacial region, however, its etiology still remains unclear. Here, we performed gene expression profiling of FD using microarray analysis to explore the key molecule events in FD development, and develop potential diagnostic markers or therapeutic targets for FD. We found that 1,881 genes exhibited differential expression with more than two-fold changes in FD compared to normal bone tissues, including 1,200 upregulated genes and 681 downregulated genes. Pathway analysis indicated that obviously activated pathways are Ribosome and ECM-receptor interaction pathways; downregulated pathways are Hepatitis C and cancer signaling pathways. We further validated the expression of ADAMTS2, one of most differentiated expressed genes, by Immunohistochemistry (IHC) in 40 of FD cases. Results showed that ADAMTS2 was significantly overexpressed in FD tissues, but rarely expressed in normal bone tissues, suggesting that ADAMTS2 could be a potential biomarker for FD. Thus, this study uncovered differentially expressed candidate genes in FD, which provides pilot data for understanding FD pathogenesis, and developing novel biomarkers for diagnosis and targeting of FD." @default.
• W97797872 created "2016-06-24" @default.
• W97797872 creator A5000593851 @default.
• W97797872 creator A5009710024 @default.
• W97797872 creator A5029956090 @default.
• W97797872 creator A5041570229 @default.
• W97797872 creator A5050787253 @default.
• W97797872 creator A5061801664 @default.
• W97797872 creator A5085127434 @default.
• W97797872 date "2014-01-01" @default.
• W97797872 modified "2023-10-05" @default.
• W97797872 title "Gene expression profiling of craniofacial fibrous dysplasia reveals ADAMTS2 overexpression as a potential marker." @default.
• W97797872 cites W1590619267 @default.
• W97797872 cites W1914982103 @default.
• W97797872 cites W1972401620 @default.
• W97797872 cites W1996098100 @default.
• W97797872 cites W2006498189 @default.
• W97797872 cites W2008296577 @default.
• W97797872 cites W2020516033 @default.
• W97797872 cites W2030246164 @default.
• W97797872 cites W2031585967 @default.
• W97797872 cites W2037267859 @default.
• W97797872 cites W2042189769 @default.
• W97797872 cites W2044229396 @default.
• W97797872 cites W2044290172 @default.
• W97797872 cites W2047492148 @default.
• W97797872 cites W2050407972 @default.
• W97797872 cites W2059298531 @default.
• W97797872 cites W2059555298 @default.
• W97797872 cites W2065316219 @default.
• W97797872 cites W2075141544 @default.
• W97797872 cites W2098023566 @default.
• W97797872 cites W2109177164 @default.
• W97797872 cites W2117313763 @default.
• W97797872 cites W2137690388 @default.
• W97797872 cites W2157630226 @default.
• W97797872 cites W2399971838 @default.
• W97797872 cites W4292462993 @default.
• W97797872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4314047" @default.
• W97797872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25674217" @default.
• W97797872 hasPublicationYear "2014" @default.
• W97797872 type Work @default.
• W97797872 sameAs 97797872 @default.
• W97797872 citedByCount "4" @default.
• W97797872 countsByYear W977978722016 @default.
• W97797872 countsByYear W977978722017 @default.
• W97797872 countsByYear W977978722018 @default.
• W97797872 countsByYear W977978722020 @default.
• W97797872 crossrefType "journal-article" @default.
• W97797872 hasAuthorship W97797872A5000593851 @default.
• W97797872 hasAuthorship W97797872A5009710024 @default.
• W97797872 hasAuthorship W97797872A5029956090 @default.
• W97797872 hasAuthorship W97797872A5041570229 @default.
• W97797872 hasAuthorship W97797872A5050787253 @default.
• W97797872 hasAuthorship W97797872A5061801664 @default.
• W97797872 hasAuthorship W97797872A5085127434 @default.
• W97797872 hasConcept C104317684 @default.
• W97797872 hasConcept C142724271 @default.
• W97797872 hasConcept C150194340 @default.
• W97797872 hasConcept C18431079 @default.
• W97797872 hasConcept C186836561 @default.
• W97797872 hasConcept C203014093 @default.
• W97797872 hasConcept C204232928 @default.
• W97797872 hasConcept C2779018089 @default.
• W97797872 hasConcept C2781245598 @default.
• W97797872 hasConcept C502942594 @default.
• W97797872 hasConcept C54355233 @default.
• W97797872 hasConcept C62478195 @default.
• W97797872 hasConcept C71924100 @default.
• W97797872 hasConcept C8415881 @default.
• W97797872 hasConcept C86803240 @default.
• W97797872 hasConceptScore W97797872C104317684 @default.
• W97797872 hasConceptScore W97797872C142724271 @default.
• W97797872 hasConceptScore W97797872C150194340 @default.
• W97797872 hasConceptScore W97797872C18431079 @default.
• W97797872 hasConceptScore W97797872C186836561 @default.
• W97797872 hasConceptScore W97797872C203014093 @default.
• W97797872 hasConceptScore W97797872C204232928 @default.
• W97797872 hasConceptScore W97797872C2779018089 @default.
• W97797872 hasConceptScore W97797872C2781245598 @default.
• W97797872 hasConceptScore W97797872C502942594 @default.
• W97797872 hasConceptScore W97797872C54355233 @default.
• W97797872 hasConceptScore W97797872C62478195 @default.
• W97797872 hasConceptScore W97797872C71924100 @default.
• W97797872 hasConceptScore W97797872C8415881 @default.
• W97797872 hasConceptScore W97797872C86803240 @default.
• W97797872 hasIssue "12" @default.
• W97797872 hasLocation W977978721 @default.
• W97797872 hasOpenAccess W97797872 @default.
• W97797872 hasPrimaryLocation W977978721 @default.
• W97797872 hasRelatedWork W1972696957 @default.
• W97797872 hasRelatedWork W2039699813 @default.
• W97797872 hasRelatedWork W2081507994 @default.
• W97797872 hasRelatedWork W2160802685 @default.
• W97797872 hasRelatedWork W2183420549 @default.
• W97797872 hasRelatedWork W2223549427 @default.
• W97797872 hasRelatedWork W2346183065 @default.
• W97797872 hasRelatedWork W2767847608 @default.

• next