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- W97801607 abstract "Non-small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, most cases are on an advanced and inoperable stage, with limited therapeutic options. Existing therapies have shown to be insufficient and novel strategies are urgently necessary. New advances in understanding the disease at cellular and molecular level however have helped researchers in devising novel strategies for therapy. These directed therapies limit cancer growth by targeting specific molecules related with tumor progression. Such strategies have shown to be more effective than chemotherapy and radiotherapy and can be complemented to existing therapeutic paradigm in augmenting beneficial outcome. Lung cancer could benefit from such innovative therapy. RNA interference (RNAi) is a sequence-specific gene silencing mechanism and, since its discovery widespread applications have pointed it as a powerful tool in cancer treatment. Several on-going clinical trials have been successfully demonstrating its potential as a novel therapeutic, including in the treatment of NSCLC. Here, we revise the recent findings concerning the therapeutic effects of molecular variations associated with NSCLC and where targeted therapies stand in its treatment, with special focus on RNAi-mediated gene silencing as a powerful strategy for NSCLC treatment. Keywords: Angiogenesis, apoptosis, monoclonal antibody, non-small cell lung cancer, RNA interference, signal transduction, small molecules, targeted therapy." @default.
- W97801607 created "2016-06-24" @default.
- W97801607 creator A5009363014 @default.
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- W97801607 creator A5041458969 @default.
- W97801607 creator A5041950062 @default.
- W97801607 date "2015-10-31" @default.
- W97801607 modified "2023-09-25" @default.
- W97801607 title "Non-Small Cell Lung Carcinoma: An Overview on Targeted Therapy" @default.
- W97801607 cites W1512138795 @default.
- W97801607 cites W1539571840 @default.
- W97801607 cites W1563958357 @default.
- W97801607 cites W156604126 @default.
- W97801607 cites W1640556854 @default.
- W97801607 cites W1651020066 @default.
- W97801607 cites W177271770 @default.
- W97801607 cites W1897972509 @default.
- W97801607 cites W1967899512 @default.
- W97801607 cites W1968656389 @default.
- W97801607 cites W1970015742 @default.
- W97801607 cites W1970110601 @default.
- W97801607 cites W1970161309 @default.
- W97801607 cites W1970332601 @default.
- W97801607 cites W1972637758 @default.
- W97801607 cites W1974050574 @default.
- W97801607 cites W1974213646 @default.
- W97801607 cites W1974888028 @default.
- W97801607 cites W1975225141 @default.
- W97801607 cites W1976211156 @default.
- W97801607 cites W1978542189 @default.
- W97801607 cites W1979438083 @default.
- W97801607 cites W1979879731 @default.
- W97801607 cites W1980161576 @default.
- W97801607 cites W1980278982 @default.
- W97801607 cites W1981717620 @default.
- W97801607 cites W1981989535 @default.
- W97801607 cites W1984621921 @default.
- W97801607 cites W1984796464 @default.
- W97801607 cites W1985937921 @default.
- W97801607 cites W1986586873 @default.
- W97801607 cites W1988257756 @default.
- W97801607 cites W1988729646 @default.
- W97801607 cites W1990577364 @default.
- W97801607 cites W1991874467 @default.
- W97801607 cites W1992785925 @default.
- W97801607 cites W1995059263 @default.
- W97801607 cites W1995066096 @default.
- W97801607 cites W1999250507 @default.
- W97801607 cites W1999825918 @default.
- W97801607 cites W2000263590 @default.
- W97801607 cites W2003549930 @default.
- W97801607 cites W2004271888 @default.
- W97801607 cites W2006167464 @default.
- W97801607 cites W2008171455 @default.
- W97801607 cites W2008521829 @default.
- W97801607 cites W2010561642 @default.
- W97801607 cites W2010726668 @default.
- W97801607 cites W2012966977 @default.
- W97801607 cites W2013091589 @default.
- W97801607 cites W2013237763 @default.
- W97801607 cites W2014370165 @default.
- W97801607 cites W2014509855 @default.
- W97801607 cites W2015047229 @default.
- W97801607 cites W2015436643 @default.
- W97801607 cites W2015700471 @default.
- W97801607 cites W2016742169 @default.
- W97801607 cites W2017046792 @default.
- W97801607 cites W2017098230 @default.
- W97801607 cites W2018729653 @default.
- W97801607 cites W2020224261 @default.
- W97801607 cites W2022317048 @default.
- W97801607 cites W2022803736 @default.
- W97801607 cites W2022978916 @default.
- W97801607 cites W2023186109 @default.
- W97801607 cites W2023561138 @default.
- W97801607 cites W2025971310 @default.
- W97801607 cites W2027017068 @default.
- W97801607 cites W2027328390 @default.
- W97801607 cites W2027954222 @default.
- W97801607 cites W2030485399 @default.
- W97801607 cites W2033978778 @default.
- W97801607 cites W2034086671 @default.
- W97801607 cites W2034482404 @default.
- W97801607 cites W2034739637 @default.
- W97801607 cites W2035440305 @default.
- W97801607 cites W2035610000 @default.
- W97801607 cites W2036954205 @default.
- W97801607 cites W2037212378 @default.
- W97801607 cites W2038875614 @default.
- W97801607 cites W2041293115 @default.
- W97801607 cites W2042148986 @default.
- W97801607 cites W2042278676 @default.
- W97801607 cites W2045061077 @default.
- W97801607 cites W2047056881 @default.
- W97801607 cites W2047185677 @default.
- W97801607 cites W2049853609 @default.
- W97801607 cites W2050146483 @default.
- W97801607 cites W2052957185 @default.