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• W97809188 abstract "Guidelines generally recommend the monitoring of serum electrolyte and creatinine concentrations in patients treated with antihypertensive therapy in order to detect potential adverse reactions to treatment. However, it is not well known to what extent these guidelines are followed in primary care. I undertook a retrospective analysis of 74096 adult patients from the General Practice Research Database with newly diagnosed hypertension and prescribed a single antihypertensive agent. Baseline biochemical testing was undertaken in 31094 patients (42%) and 37365 (50%) patients had at least one biochemical monitoring test in the year after starting antihypertensive treatment. Monitoring was significantly more likely in patients treated with angiotensin-converting enzyme inhibitors than thiazide diuretics, older patients, and patients with diabetes mellitus. These patient factors were significantly associated with monitoring when multiple imputation was used to control for the potential bias introduced by missing data. In general, follow-up monitoring was infrequent, irregular, and did not change in response to events such as abnormal test results. Patients who were monitored after the initiation of antihypertensive treatment were significantly more likely to be admitted to hospital and discontinue therapy, which is likely a result of reactive instead of planned monitoring. Using propensity score methods to control for confounding, I demonstrated a decreased risk of these same adverse outcomes in patients with baseline testing, which may be because these patients were less likely to have any follow-up monitoring and not the protective effect of the baseline testing. I described several barriers to biochemical monitoring including the lack of consensus in published guidelines, uncertain responsibility for monitoring, patient nonadherence, and absence of alerts or reminders to monitor. More work is needed to improve the primary evidence base for monitoring and to improve the guidelines on the nature and frequency of monitoring for adverse drug reactions, particularly in patients at greater risk of drug-induced harm." @default.
• W97809188 created "2016-06-24" @default.
• W97809188 creator A5089104186 @default.
• W97809188 date "2011-12-01" @default.
• W97809188 modified "2023-09-26" @default.
• W97809188 title "Monitoring of patients for the development of adverse reactions to antihypertensive drugs in general practice" @default.
• W97809188 cites W131453520 @default.
• W97809188 cites W140734583 @default.
• W97809188 cites W1494196240 @default.
• W97809188 cites W1496300613 @default.
• W97809188 cites W1512231237 @default.
• W97809188 cites W1522854245 @default.
• W97809188 cites W1528579232 @default.
• W97809188 cites W1529941908 @default.
• W97809188 cites W1533670065 @default.
• W97809188 cites W1536688534 @default.
• W97809188 cites W1538461644 @default.
• W97809188 cites W1571655889 @default.
• W97809188 cites W1572896760 @default.
• W97809188 cites W1577119245 @default.
• W97809188 cites W1580788756 @default.
• W97809188 cites W1589671665 @default.
• W97809188 cites W1598021936 @default.
• W97809188 cites W1599621040 @default.
• W97809188 cites W1601517327 @default.
• W97809188 cites W1607621392 @default.
• W97809188 cites W1608346277 @default.
• W97809188 cites W1615247714 @default.
• W97809188 cites W1691887444 @default.
• W97809188 cites W1692839365 @default.
• W97809188 cites W1707746270 @default.
• W97809188 cites W1710832400 @default.
• W97809188 cites W1742494301 @default.
• W97809188 cites W175212988 @default.
• W97809188 cites W1791338516 @default.
• W97809188 cites W1852065298 @default.
• W97809188 cites W1884861631 @default.
• W97809188 cites W1956362123 @default.
• W97809188 cites W1960964799 @default.
• W97809188 cites W1963880571 @default.
• W97809188 cites W1964475341 @default.
• W97809188 cites W1968030991 @default.
• W97809188 cites W1969067106 @default.
• W97809188 cites W1971045763 @default.
• W97809188 cites W1971954813 @default.
• W97809188 cites W1972412925 @default.
• W97809188 cites W1972918001 @default.
• W97809188 cites W1973013742 @default.
• W97809188 cites W1973426926 @default.
• W97809188 cites W1973474526 @default.
• W97809188 cites W1973477276 @default.
• W97809188 cites W1975617388 @default.
• W97809188 cites W1979202959 @default.
• W97809188 cites W1980533403 @default.
• W97809188 cites W1981501248 @default.
• W97809188 cites W1982525766 @default.
• W97809188 cites W1982831088 @default.
• W97809188 cites W1982910299 @default.
• W97809188 cites W1983650592 @default.
• W97809188 cites W1983722797 @default.
• W97809188 cites W1984154610 @default.
• W97809188 cites W1984541790 @default.
• W97809188 cites W1985110513 @default.
• W97809188 cites W1985681783 @default.
• W97809188 cites W1985883733 @default.
• W97809188 cites W1988304729 @default.
• W97809188 cites W1989158466 @default.
• W97809188 cites W1989377468 @default.
• W97809188 cites W1992253867 @default.
• W97809188 cites W1992746042 @default.
• W97809188 cites W1995260041 @default.
• W97809188 cites W1995626058 @default.
• W97809188 cites W1995767550 @default.
• W97809188 cites W1996239854 @default.
• W97809188 cites W1996307960 @default.
• W97809188 cites W1999420609 @default.
• W97809188 cites W2000161481 @default.
• W97809188 cites W2003001596 @default.
• W97809188 cites W2005177820 @default.
• W97809188 cites W2005519248 @default.
• W97809188 cites W2006157113 @default.
• W97809188 cites W2006316803 @default.
• W97809188 cites W2006949475 @default.
• W97809188 cites W2007664849 @default.
• W97809188 cites W2008055393 @default.
• W97809188 cites W2008174801 @default.
• W97809188 cites W2008291984 @default.
• W97809188 cites W2008706768 @default.
• W97809188 cites W2010993971 @default.
• W97809188 cites W2011744517 @default.
• W97809188 cites W2011795361 @default.
• W97809188 cites W2013785415 @default.
• W97809188 cites W2015501013 @default.
• W97809188 cites W2015935026 @default.
• W97809188 cites W2016168995 @default.
• W97809188 cites W2016403661 @default.
• W97809188 cites W2016503459 @default.
• W97809188 cites W2016889447 @default.
• W97809188 cites W2017315940 @default.
• W97809188 cites W2017948178 @default.

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