FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W97822244> ?p ?o ?g. }

• W97822244 endingPage "724" @default.
• W97822244 startingPage "719" @default.
• W97822244 abstract "The antipsychotic drugs of the phenothiazine and the butyrophenone groups are known to increase the synthesis and release of catecholamines as a consequence of their ability to block central catecholamine receptors (Carlsson and Lindqvist, 1973). This feedback-mediated activation of catecholamine turnover should serve to partially neutralize the receptor blocking action of these drugs. If so, inhibition of the compensatory increase in the catecholamine synthesis should potentiate the behavioural effects induced by drugs that primarily act by blocking central catecholamine receptors. In fact we have found such a potentiation by α-methyltyrosine on the behavioural suppression induced by the antipsychotic drugs haloperidol, pimozide, chlorpromazine or thioridazine on feed-reinforced lever-pressing performance in rats. However, the behaviour effects of the noradrenaline (NA) receptor blocking agent phenoxybenzamine could not be potentiated by pre-treatment with α-methyltyrosine, nor could the dopamine (DA) β-hydroxylase inhibitor FLA-63 potentiate the behavioural effects of haloperidol, chlorpromazine or thioridazine, indicating that a blockade of central DA receptors appears to be more essential for the behavioural effects observed. Also in schizophrenic patients α-methyltyrosine has been found to markedly potentiate the antipsychotic effects of chlorpromazine or thioridazine (Carlsson et al., 1972, 1973). The potentiation observed was of similar magnitude to that found in the animal experiments. Taken together, the observations from the clinical and laboratory studies support the hypothesis that the antipsychotic action of neuroleptic drugs like phenothiazine and butyrophenones is due to blockade of central catecholamine, especially DA, receptors. This may point to that at least part of the symptoms displayed in schizophrenia, may be mediated via increased neurotransmission in central DA neurons. By the use of the discriminative avoidance situation it is possible to study a behavioural disturbance induced by an increased DA receptor activation. This disturbance induced by L–Dopa, amphetamine or ampomorphine manifests itself as a loss of discriminative, but not of avoidance performance, i.e. the animals perform a conditioned avoidance response but perform incorrectly. This biochemically induced abnormality could be completely normalized by antipsychotic drugs that block central DA receptors. The NA receptor blocking agent phenoxybenzamine had no effect on the Dopa-induced abnormal behaviour, further indicating an involvement of central DA mechanisms. These data show that antipsychotic drugs, that act by blocking central DA receptors, not only specifically inhibit normal behaviour but can also improve the abnormal behaviour in animals with an increased activation of central DA receptors, which further point to the possibility that a disturbance of central DA neurons may be involved in the symptomatology in schizophrenia." @default.
• W97822244 created "2016-06-24" @default.
• W97822244 creator A5057387570 @default.
• W97822244 creator A5076417915 @default.
• W97822244 date "1978-01-01" @default.
• W97822244 modified "2023-09-23" @default.
• W97822244 title "EFFECTS OF ANTIPSYCHOTIC DRUGS ON NORMAL AND ABNORMAL ANIMAL BEHAVIOUR" @default.
• W97822244 cites W1972685862 @default.
• W97822244 cites W1985877098 @default.
• W97822244 cites W1991854087 @default.
• W97822244 cites W1995381344 @default.
• W97822244 cites W2000589316 @default.
• W97822244 cites W2005994304 @default.
• W97822244 cites W2029741550 @default.
• W97822244 cites W2046849579 @default.
• W97822244 cites W2055214203 @default.
• W97822244 cites W2060937351 @default.
• W97822244 cites W2074976172 @default.
• W97822244 cites W2079730258 @default.
• W97822244 cites W2193524624 @default.
• W97822244 doi "https://doi.org/10.1016/b978-1-4832-8322-7.50105-9" @default.
• W97822244 hasPublicationYear "1978" @default.
• W97822244 type Work @default.
• W97822244 sameAs 97822244 @default.
• W97822244 citedByCount "0" @default.
• W97822244 crossrefType "book-chapter" @default.
• W97822244 hasAuthorship W97822244A5057387570 @default.
• W97822244 hasAuthorship W97822244A5076417915 @default.
• W97822244 hasConcept C118552586 @default.
• W97822244 hasConcept C126322002 @default.
• W97822244 hasConcept C134018914 @default.
• W97822244 hasConcept C170493617 @default.
• W97822244 hasConcept C185592680 @default.
• W97822244 hasConcept C2775894120 @default.
• W97822244 hasConcept C2776412080 @default.
• W97822244 hasConcept C2777845345 @default.
• W97822244 hasConcept C2778468042 @default.
• W97822244 hasConcept C2778775820 @default.
• W97822244 hasConcept C2779583389 @default.
• W97822244 hasConcept C2780494398 @default.
• W97822244 hasConcept C2780688371 @default.
• W97822244 hasConcept C2780864610 @default.
• W97822244 hasConcept C2780948584 @default.
• W97822244 hasConcept C2910202354 @default.
• W97822244 hasConcept C513476851 @default.
• W97822244 hasConcept C71924100 @default.
• W97822244 hasConcept C98274493 @default.
• W97822244 hasConceptScore W97822244C118552586 @default.
• W97822244 hasConceptScore W97822244C126322002 @default.
• W97822244 hasConceptScore W97822244C134018914 @default.
• W97822244 hasConceptScore W97822244C170493617 @default.
• W97822244 hasConceptScore W97822244C185592680 @default.
• W97822244 hasConceptScore W97822244C2775894120 @default.
• W97822244 hasConceptScore W97822244C2776412080 @default.
• W97822244 hasConceptScore W97822244C2777845345 @default.
• W97822244 hasConceptScore W97822244C2778468042 @default.
• W97822244 hasConceptScore W97822244C2778775820 @default.
• W97822244 hasConceptScore W97822244C2779583389 @default.
• W97822244 hasConceptScore W97822244C2780494398 @default.
• W97822244 hasConceptScore W97822244C2780688371 @default.
• W97822244 hasConceptScore W97822244C2780864610 @default.
• W97822244 hasConceptScore W97822244C2780948584 @default.
• W97822244 hasConceptScore W97822244C2910202354 @default.
• W97822244 hasConceptScore W97822244C513476851 @default.
• W97822244 hasConceptScore W97822244C71924100 @default.
• W97822244 hasConceptScore W97822244C98274493 @default.
• W97822244 hasLocation W978222441 @default.
• W97822244 hasOpenAccess W97822244 @default.
• W97822244 hasPrimaryLocation W978222441 @default.
• W97822244 hasRelatedWork W1930849785 @default.
• W97822244 hasRelatedWork W1972557067 @default.
• W97822244 hasRelatedWork W1983788409 @default.
• W97822244 hasRelatedWork W1987176769 @default.
• W97822244 hasRelatedWork W2065307663 @default.
• W97822244 hasRelatedWork W2085631401 @default.
• W97822244 hasRelatedWork W2166212422 @default.
• W97822244 hasRelatedWork W2411949260 @default.
• W97822244 hasRelatedWork W2728288507 @default.
• W97822244 hasRelatedWork W97822244 @default.
• W97822244 isParatext "false" @default.
• W97822244 isRetracted "false" @default.
• W97822244 magId "97822244" @default.
• W97822244 workType "book-chapter" @default.