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- W978258688 abstract "Many potentially beneficial probiotics often prove to be physiologically fragile, a significant limitation in clinical applications. Improving probiotic stress tolerance and the ability to grow and survive in foods prior to ingestion and subsequently within the animal host is an important clinical goal. The pathobiotechnology concept seeks to attain this goal, ultimately leading to the development of improved probiotic strains. A primary focus of this approach involves equipping probiotic bacteria with the genetic elements necessary to overcome the many stresses encountered during the probiotic life cycle (both external and internal to the host) as well as enabling probiotics to better deal with invading pathogens. Engineered probiotics thus have the potential to alleviate the symptoms of chronic gastrointestinal disorders and associated sequelae, to fight infection, modulate the immune system, and act as delivery vehicles for bioactive molecules. Notwithstanding these impressive health benefits, probiotic research has really only begun to achieve scientific credibility over the last decade. However, the increasing emergence of antibiotic resistance, coupled with a significant decline in production of new antibacterials, means that probiotics are finally coming of age, representing a real alternative to traditional drug-based therapies." @default.
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- W978258688 date "2010-01-01" @default.
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- W978258688 title "Bioengineering of Bacteria" @default.
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