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- W97852 abstract "Polycystic ovary syndrome (PCOS), a prevalent disorder in young women, is characterized by chronic anovulation and hyperandrogenism. One of the major concerns in women with PCOS has been infertility, a consequence of chronic oligo- or anovulation. However, even after ovulation is restored, either pharmacologically or via lifestyle interventions, women with PCOS exhibit a surprisingly high rate of spontaneous miscarriage. Several studies have shown that insulin resistance and hyperinsulinemia play an integral role in early pregnancy loss in PCOS. However, the exact underlying mechanism remains poorly understood. Several different mechanisms for the effect of hyperinsulinemia have been proposed, including its effect on oocyte maturation, glucose uptake and metabolism, implantation, and alteration of expression of HOXA10 genes. One of the most compelling hypotheses is the effect of hyperinsulinemic insulin resistance on decreasing serum and endometrial glycodelin and insulin-like growth factor binding protein-1 concentrations, major endometrial secretory proteins that play an important role in implantation and maintenance of pregnancy. The accumulated evidence supports the use of insulin sensitizing drugs like metformin in the treatment of infertility in PCOS, and suggests that it may reduce miscarriages in the disorder. However, the duration of metformin treatment during pregnancy in women with PCOS is controversial. Although metformin appears to have a reassuring safety profile during pregnancy, future rigorous, randomized controlled trials are needed to confirm its efficacy and safety under these conditions." @default.
- W97852 created "2016-06-24" @default.
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- W97852 date "2007-01-01" @default.
- W97852 modified "2023-10-14" @default.
- W97852 title "Insulin Resistance and Early Pregnancy Loss in Polycystic Ovary Syndrome" @default.
- W97852 cites W14695486 @default.
- W97852 cites W1962519237 @default.
- W97852 cites W1963745146 @default.
- W97852 cites W1963881210 @default.
- W97852 cites W1964564069 @default.
- W97852 cites W1969062482 @default.
- W97852 cites W1971110774 @default.
- W97852 cites W1974641303 @default.
- W97852 cites W1975856824 @default.
- W97852 cites W1977143238 @default.
- W97852 cites W1983284888 @default.
- W97852 cites W1986163467 @default.
- W97852 cites W1987671433 @default.
- W97852 cites W1988490579 @default.
- W97852 cites W1996083033 @default.
- W97852 cites W1998710143 @default.
- W97852 cites W1998858155 @default.
- W97852 cites W1999516495 @default.
- W97852 cites W2000320091 @default.
- W97852 cites W2003517642 @default.
- W97852 cites W2011807431 @default.
- W97852 cites W2011921903 @default.
- W97852 cites W2020985812 @default.
- W97852 cites W2025214989 @default.
- W97852 cites W2029305137 @default.
- W97852 cites W2029329135 @default.
- W97852 cites W2032442332 @default.
- W97852 cites W2039132490 @default.
- W97852 cites W2044333241 @default.
- W97852 cites W2044426380 @default.
- W97852 cites W2051770308 @default.
- W97852 cites W2054148469 @default.
- W97852 cites W2056981805 @default.
- W97852 cites W2063731066 @default.
- W97852 cites W2068087033 @default.
- W97852 cites W2072840911 @default.
- W97852 cites W2077860383 @default.
- W97852 cites W2078214818 @default.
- W97852 cites W2079382212 @default.
- W97852 cites W2079915785 @default.
- W97852 cites W2088405378 @default.
- W97852 cites W2089202687 @default.
- W97852 cites W2089518257 @default.
- W97852 cites W2095252238 @default.
- W97852 cites W2096601431 @default.
- W97852 cites W2101640392 @default.
- W97852 cites W2108512287 @default.
- W97852 cites W2108662489 @default.
- W97852 cites W2109155665 @default.
- W97852 cites W2110651221 @default.
- W97852 cites W2110993745 @default.
- W97852 cites W2115740633 @default.
- W97852 cites W2118503490 @default.
- W97852 cites W2123266289 @default.
- W97852 cites W2141428775 @default.
- W97852 cites W2141802887 @default.
- W97852 cites W2141828378 @default.
- W97852 cites W2143877744 @default.
- W97852 cites W2149717321 @default.
- W97852 cites W2150312049 @default.
- W97852 cites W2157803698 @default.
- W97852 cites W2160115983 @default.
- W97852 cites W2167950650 @default.
- W97852 cites W2168018194 @default.
- W97852 cites W2169777843 @default.
- W97852 cites W2171862525 @default.
- W97852 cites W2247912926 @default.
- W97852 cites W2319224462 @default.
- W97852 cites W2402189937 @default.
- W97852 cites W4229598164 @default.
- W97852 cites W4230459941 @default.
- W97852 cites W4237267303 @default.
- W97852 cites W4238681909 @default.
- W97852 cites W4239904712 @default.
- W97852 cites W4240900393 @default.
- W97852 cites W4243286929 @default.
- W97852 cites W4244439928 @default.
- W97852 cites W4244849366 @default.
- W97852 cites W4248823988 @default.
- W97852 cites W4249124461 @default.
- W97852 cites W4249219434 @default.
- W97852 cites W4254005293 @default.
- W97852 cites W4292365867 @default.
- W97852 cites W87051894 @default.
- W97852 doi "https://doi.org/10.1007/978-1-59745-310-3_33" @default.
- W97852 hasPublicationYear "2007" @default.
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