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- W978597617 abstract "Corticosteroids can potentially interfere with virtually every phase of inflammatory and immunologic reactivity. Generally, kinetics and circulatory patterns of leukocytes are more sensitive to corticosteroid modulation than are the functional effects of cells. In addition, various classes and subclasses of leukocytes appear to differ in sensitivity to corticosteroid effects. The precise mechanisms of their effects are still unclear. However, it is likely that they relate at least in part to specific receptor interaction of corticosteroid with the involved cells. Glucocorticosteroids display a variety of complex effects on different biologic systems and cell types. This review focuses on the mechanisms of action of these agents on inflammatory and immune responses, particularly with respect to human biology in vivo and considers the effects of glucocorticosteroids on vascular tissue, leukocyte kinetics and function, and various humoral factors involved in these responses. Many of the cellular and tissue effects of corticosteroids are triggered through an interaction with intracytoplasmic steroid receptors in the target cell. The steroid-receptor complexes thus formed migrate to and become associated with the cell nucleus. This leads to the synthesis of specific mRNA that, in turn, induces new protein synthesis. The newly synthesized protein may be an enzyme or an inhibitory protein, and it is highly likely that such a mechanism is responsible for the modulatory effect of corticosteroids on leukocytes involved in inflammatory or immune responses." @default.
- W978597617 created "2016-06-24" @default.
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- W978597617 date "1978-01-01" @default.
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- W978597617 title "Chapter 19. Mechanisms of Action of Glucocorticosteroids" @default.
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- W978597617 doi "https://doi.org/10.1016/s0065-7743(08)60622-3" @default.
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