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- W979339783 abstract "To verify the optimal cut-off points for overweight and obesity in Chinese adults based on the relationship of baseline body mass index(BMI)to all-cause mortality,and incidence of cardiovascular diseases from pooled data of Chinese cohorts.Methods The prospective study data of existing cohort studies in China were collected,and the age-adjusted all-cause mortality stratified by BMI were estimated.The similar analysis was repeated after excluding deaths within the first three years of follow-up and after excluding smokers.The incidence of age-adjusted coronary heart idsease(CHD)and stroke stratified by BMI were also analyzed.Multiple Cox regression coefficients of BMI for the incidence of CHDand stroke after controlling other risk factors were pooled utilizing the methods of weighting by inverse of variance to reveal whether BMI had independent effect and its strength on the incidence of CHD and stroke.Results The data of4cohorts including76227persons,with745346person-years of follow-up were collected and analyzed.The age-adjusted all-cause mortality stratified by BMI showed a U-shaped curve,even after excluding deaths within the first three years of follow-up and excluding smokers.Age-adjusted all-cause mortality increased whenBMIwas lower than18.5and higher than28.The incidence of CHD and stroke,especially ishemic stroke increased with increasingBMI,this was consistent with parallel increasing of risk factors.Cox regression analysis showed that BMI was an independent risk factor for bothCHDand stroke,Eachamount of 2kg/m^2increase in baseline BMImight cause15.4%,6.1%and18.8%increase in relative risk of CHD,total stroke and ischemic stroke.Reduction of BMItounder24might prevent the incidence of CHD by11%and that of strokeby15%for men,and22A%of both diseases for wonen.Conclusion BMI≤18.5,24-27.9and≥28(kg/m^2)is the appropriate cut-off points for underweight,overweight and obesity in Chinese adults." @default.
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- W979339783 date "2002-01-01" @default.
- W979339783 modified "2023-09-26" @default.
- W979339783 title "Effect of Body Mass Index on All—cause Mortality and Incidence of Cardiovascular Diseases—Report for Meta—Analysis of Prospective Studies on Optimal Cut—off Points of Body Mass Index in Chinese Ad" @default.
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