Matches in SemOpenAlex for { <https://semopenalex.org/work/W9793971> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W9793971 endingPage "376" @default.
- W9793971 startingPage "369" @default.
- W9793971 abstract "1. The effects of phentolamine (500 micrograms/min) on platelet aggregability in vivo at rest and during adrenaline infusion were assessed by ex vivo filtragometry and measurements of plasma beta-thromboglobulin levels in 10 healthy male subjects. Plasma levels of von Willebrand factor antigen and free fatty acids were also measured. 2. Adrenaline induced marked and expected increases in heart rate and systolic blood pressure and decreased diastolic blood pressure when venous plasma adrenaline levels were elevated from 0.12 +/- 0.02 to 2.9 +/- 0.3 nmol/l (P less than 0.01). 3. Adrenaline caused platelet activation in vivo. Ex vivo filtragometry readings were shortened by 58 +/- 9% (P less than 0.01), plasma beta-thromboglobulin levels increased by 99 +/- 44% (P less than 0.01) and platelet counts increased by 26 +/- 6% (P less than 0.01). Plasma levels of von Willebrand factor antigen and free fatty acids increased by 53 +/- 5% and 475 +/- 113% (both P less than 0.01), respectively. 4. Phentolamine enhanced the beta-adrenergic vasodilator responses to adrenaline, as both the decrease in diastolic blood pressure and the reflexogenic increase in heart rate were enhanced (both P less than 0.01). Marked elevations in plasma noradrenaline levels were found during infusions of phentolamine and adrenaline (P less than 0.001). 5. Phentolamine did not alter platelet indices at rest, but abolished adrenaline-induced platelet activation, as filtragometry readings, plasma beta-thromboglobulin levels and platelet counts remained at, or below, resting levels. Responses of plasma levels of von Willebrand factor antigen and free fatty acids to adrenaline were not influenced by phentolamine and did not seem to influence platelet responses.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W9793971 created "2016-06-24" @default.
- W9793971 creator A5038680196 @default.
- W9793971 creator A5061424607 @default.
- W9793971 creator A5068373464 @default.
- W9793971 creator A5089563207 @default.
- W9793971 date "1992-04-01" @default.
- W9793971 modified "2023-10-16" @default.
- W9793971 title "<i>α</i>-Adrenoceptor blockade by phentolamine inhibits adrenaline-induced platelet activation <i>in vivo</i> without affecting resting measurements" @default.
- W9793971 doi "https://doi.org/10.1042/cs0820369" @default.
- W9793971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1315646" @default.
- W9793971 hasPublicationYear "1992" @default.
- W9793971 type Work @default.
- W9793971 sameAs 9793971 @default.
- W9793971 citedByCount "39" @default.
- W9793971 countsByYear W97939712013 @default.
- W9793971 countsByYear W97939712014 @default.
- W9793971 countsByYear W97939712015 @default.
- W9793971 countsByYear W97939712016 @default.
- W9793971 countsByYear W97939712018 @default.
- W9793971 countsByYear W97939712019 @default.
- W9793971 countsByYear W97939712020 @default.
- W9793971 countsByYear W97939712021 @default.
- W9793971 countsByYear W97939712022 @default.
- W9793971 countsByYear W97939712023 @default.
- W9793971 crossrefType "journal-article" @default.
- W9793971 hasAuthorship W9793971A5038680196 @default.
- W9793971 hasAuthorship W9793971A5061424607 @default.
- W9793971 hasAuthorship W9793971A5068373464 @default.
- W9793971 hasAuthorship W9793971A5089563207 @default.
- W9793971 hasConcept C126322002 @default.
- W9793971 hasConcept C134018914 @default.
- W9793971 hasConcept C150903083 @default.
- W9793971 hasConcept C185592680 @default.
- W9793971 hasConcept C207001950 @default.
- W9793971 hasConcept C2775859304 @default.
- W9793971 hasConcept C2777953023 @default.
- W9793971 hasConcept C2778151854 @default.
- W9793971 hasConcept C2779394231 @default.
- W9793971 hasConcept C2780253649 @default.
- W9793971 hasConcept C2781318281 @default.
- W9793971 hasConcept C3018697912 @default.
- W9793971 hasConcept C71924100 @default.
- W9793971 hasConcept C84393581 @default.
- W9793971 hasConcept C86803240 @default.
- W9793971 hasConcept C89560881 @default.
- W9793971 hasConceptScore W9793971C126322002 @default.
- W9793971 hasConceptScore W9793971C134018914 @default.
- W9793971 hasConceptScore W9793971C150903083 @default.
- W9793971 hasConceptScore W9793971C185592680 @default.
- W9793971 hasConceptScore W9793971C207001950 @default.
- W9793971 hasConceptScore W9793971C2775859304 @default.
- W9793971 hasConceptScore W9793971C2777953023 @default.
- W9793971 hasConceptScore W9793971C2778151854 @default.
- W9793971 hasConceptScore W9793971C2779394231 @default.
- W9793971 hasConceptScore W9793971C2780253649 @default.
- W9793971 hasConceptScore W9793971C2781318281 @default.
- W9793971 hasConceptScore W9793971C3018697912 @default.
- W9793971 hasConceptScore W9793971C71924100 @default.
- W9793971 hasConceptScore W9793971C84393581 @default.
- W9793971 hasConceptScore W9793971C86803240 @default.
- W9793971 hasConceptScore W9793971C89560881 @default.
- W9793971 hasIssue "4" @default.
- W9793971 hasLocation W97939711 @default.
- W9793971 hasLocation W97939712 @default.
- W9793971 hasOpenAccess W9793971 @default.
- W9793971 hasPrimaryLocation W97939711 @default.
- W9793971 hasRelatedWork W1841690979 @default.
- W9793971 hasRelatedWork W1970679878 @default.
- W9793971 hasRelatedWork W2038512896 @default.
- W9793971 hasRelatedWork W2057537203 @default.
- W9793971 hasRelatedWork W2093919627 @default.
- W9793971 hasRelatedWork W2135033561 @default.
- W9793971 hasRelatedWork W2146779265 @default.
- W9793971 hasRelatedWork W2149916543 @default.
- W9793971 hasRelatedWork W2292878995 @default.
- W9793971 hasRelatedWork W2460584456 @default.
- W9793971 hasVolume "82" @default.
- W9793971 isParatext "false" @default.
- W9793971 isRetracted "false" @default.
- W9793971 magId "9793971" @default.
- W9793971 workType "article" @default.