Matches in SemOpenAlex for { <https://semopenalex.org/work/W9794014> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W9794014 endingPage "81" @default.
- W9794014 startingPage "I174" @default.
- W9794014 abstract "The calcium antagonists, diltiazem and nifedipine, are effective in mild-to-moderate chronic essential hypertension. The overall responder rate is 80%. Diastolic blood pressure is lowered by 10-15% at rest and during exercise. Systolic blood pressure is reduced only at rest. Heart rate may be unchanged by nifedipine and lowered by diltiazem. Both drugs lead to a decrease of peripheral resistance by 15-20% at rest and 30% during work. As a consequence of afterload reduction, cardiac output, stroke index, and stroke work index increased by 17, 21, and 7% with nifedipine and 34, 26, and 20% with diltiazem. During exercise, these changes are even more pronounced. However, pulmonary artery pressure and pulmonary vascular resistance are reduced only by nifedipine, not by diltiazem. Presumably due to this combined preload and afterload reduction, nifedipine therapy is associated with a reflex activation of the sympathetic nervous system in all cases, with an increase in norepinephrine plasma concentration and, sometimes, tachycardia. Diltiazem, however, has the advantage of being a potent blood pressure-lowering agent, with afterload reduction and increased stroke index, with less pronounced catecholamine increase, and without tachycardia. Side effects with this drug are rare, and long-term therapy is well tolerated." @default.
- W9794014 created "2016-06-24" @default.
- W9794014 creator A5026987136 @default.
- W9794014 creator A5031354566 @default.
- W9794014 creator A5086952377 @default.
- W9794014 creator A5090234208 @default.
- W9794014 date "1983-02-01" @default.
- W9794014 modified "2023-09-26" @default.
- W9794014 title "Role of calcium antagonists in the treatment of essential hypertension." @default.
- W9794014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6831651" @default.
- W9794014 hasPublicationYear "1983" @default.
- W9794014 type Work @default.
- W9794014 sameAs 9794014 @default.
- W9794014 citedByCount "39" @default.
- W9794014 crossrefType "journal-article" @default.
- W9794014 hasAuthorship W9794014A5026987136 @default.
- W9794014 hasAuthorship W9794014A5031354566 @default.
- W9794014 hasAuthorship W9794014A5086952377 @default.
- W9794014 hasAuthorship W9794014A5090234208 @default.
- W9794014 hasConcept C123576724 @default.
- W9794014 hasConcept C126322002 @default.
- W9794014 hasConcept C139940330 @default.
- W9794014 hasConcept C164705383 @default.
- W9794014 hasConcept C178853913 @default.
- W9794014 hasConcept C2776741139 @default.
- W9794014 hasConcept C2777953023 @default.
- W9794014 hasConcept C2779066535 @default.
- W9794014 hasConcept C2780283014 @default.
- W9794014 hasConcept C42219234 @default.
- W9794014 hasConcept C48277249 @default.
- W9794014 hasConcept C519063684 @default.
- W9794014 hasConcept C58245268 @default.
- W9794014 hasConcept C71924100 @default.
- W9794014 hasConcept C84393581 @default.
- W9794014 hasConceptScore W9794014C123576724 @default.
- W9794014 hasConceptScore W9794014C126322002 @default.
- W9794014 hasConceptScore W9794014C139940330 @default.
- W9794014 hasConceptScore W9794014C164705383 @default.
- W9794014 hasConceptScore W9794014C178853913 @default.
- W9794014 hasConceptScore W9794014C2776741139 @default.
- W9794014 hasConceptScore W9794014C2777953023 @default.
- W9794014 hasConceptScore W9794014C2779066535 @default.
- W9794014 hasConceptScore W9794014C2780283014 @default.
- W9794014 hasConceptScore W9794014C42219234 @default.
- W9794014 hasConceptScore W9794014C48277249 @default.
- W9794014 hasConceptScore W9794014C519063684 @default.
- W9794014 hasConceptScore W9794014C58245268 @default.
- W9794014 hasConceptScore W9794014C71924100 @default.
- W9794014 hasConceptScore W9794014C84393581 @default.
- W9794014 hasIssue "2 Pt 2" @default.
- W9794014 hasLocation W97940141 @default.
- W9794014 hasOpenAccess W9794014 @default.
- W9794014 hasPrimaryLocation W97940141 @default.
- W9794014 hasRelatedWork W2001738387 @default.
- W9794014 hasRelatedWork W2003839951 @default.
- W9794014 hasRelatedWork W2066963790 @default.
- W9794014 hasRelatedWork W2135735905 @default.
- W9794014 hasRelatedWork W2169190460 @default.
- W9794014 hasRelatedWork W2270239738 @default.
- W9794014 hasRelatedWork W2396243630 @default.
- W9794014 hasRelatedWork W2409309343 @default.
- W9794014 hasRelatedWork W2414823484 @default.
- W9794014 hasRelatedWork W9794014 @default.
- W9794014 hasVolume "52" @default.
- W9794014 isParatext "false" @default.
- W9794014 isRetracted "false" @default.
- W9794014 magId "9794014" @default.
- W9794014 workType "article" @default.