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• W97940181 endingPage "37" @default.
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• W97940181 abstract "Phenomenological studies on T cell-mediated cytotoxicity in vitro have been extensively reviewed (Perlmann and Holm 1969; Cerottini and Brunner 1974; Golstein and Smith 1977; Henney 1977; Martz 1977; Berke 1980; Sanderson 1981; Henkart 1985; Berke 1989a; Young 1989; Tschopp and Nabholz 1990; Duke 1991; Golstein et al. 1991; Sitkovsky and Henkart 1993). Based on these studies, two major molecular pathways for the lethal hit stage of T cell-mediated cytotoxicity have been proposed. The first pathway involves granule exocytosis and perforin release and was detected about 10 years ago (Henkart 1985; Podack 1985). When a cytotoxic T lymphocyte (CTL) encounters a target cell, the channel-forming molecule perforin and serine-esterases from CTL granules are released at the interface between the CTL and the target cell. Perforin molecules then form channels within the target cell membrane, which, together with some contribution from serine-esterases (Shiver et al. 1992; Shi et al. 1992), lead to target cell death. The second pathway involves direct effector cell-target cell membrane interactions during which transduction of a signal within the target cell occurs leading to its death. Striking recent progress has led to demonstration of the use of both pathways by cytotoxic" @default.
• W97940181 created "2016-06-24" @default.
• W97940181 creator A5079533029 @default.
• W97940181 date "1995-01-01" @default.
• W97940181 modified "2023-09-25" @default.
• W97940181 title "Fas-Based T Cell-Mediated Cytotoxicity" @default.
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• W97940181 doi "https://doi.org/10.1007/978-3-642-79414-8_2" @default.
• W97940181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7539731" @default.
• W97940181 hasPublicationYear "1995" @default.
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