FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W979583005> ?p ?o ?g. }

• W979583005 endingPage "210" @default.
• W979583005 startingPage "209" @default.
• W979583005 abstract "Case Report A 38-year-old woman with alcoholic cirrhosis was admitted with a recurrent lower extremity rash. She had presented 1 year prior with a history of alcohol abuse, abdominal pain, fatigue, and a violaceous rash over the abdomen and proximal lower extremities. A skin biopsy showed multiple small vessels with calcification of the outer wall suggesting calciphylaxis. The patient was treated with sodium thiosulfate 25 mg intravenously 3 times weekly and serial wound debridement. She had symptom improvement within 3 weeks and resolution of the rash. One year later, the patient presented with recurrence of the painful violaceous rash (Figure 1). She denied any alcohol use over the last year. She had not been receiving albumin infusions or blood transfusions, and her body mass index (BMI) was 22 kg/m2. Evidence of a healed skin graft was noted on her left thigh, with surrounding tender punctate erythema. Her calcium, phosphorus, parathyroid hormone, creatinine, and protein C and S levels were normal. An abdominal CT was significant for findings consistent with cirrhosis. The patient was started on sodium thiosulfate therapy and local wound care, and responded well without recurrence to date.Figure 1.: Painful violaceous rash on lower extremities due to calciphylaxis.Calciphylaxis is a rare, life-threatening syndrome characterized by cutaneous ischemic necrosis secondary to vascular calcification. It is seen almost exclusively in end-stage renal disease, but has been associated with cirrhosis in 9 case reports. The pathogenesis of calciphylaxis is unclear, but commonly described risk factors include female sex, obesity, protein C and S deficiency, corticosteroid use, albumin or blood transfusions, and high calcium-phosphorus product.1 Clinically, calciphylaxis presents with tender violaceous skin mottling that progresses to blackened regions of eschar formation and non-healing ulceration. This usually occurs on the fat-containing tissues of the trunk, genitals, and medial thigh.2 Mortality from calciphylaxis has been estimated at 52%, mostly secondary to superimposed sepsis.1 Management strategies include lowering the calcium-phosphorus product, anti-inflammatory therapy, and aggressive wound care. Sodium thiosulfate, an emerging therapy for calciphylaxis, acts by binding calcium and decreasing reactive oxygen species.2 Our patient is notable for not exhibiting many of the previously identified risk factors for calciphylaxis. Further studies are necessary to assess factors that pose an increased risk for calciphylaxis in patients with liver disease. Given the high mortality of this condition, prompt recognition and treatment in cirrhotic patients presenting with rash is essential. Disclosures Author contributions: All authors participated equally in the creation of this manuscript. E. Akhtar is the article guarantor. Financial disclosure: None to report. Informed consent was obtained for this case report. Received: December 2, 2015; Accepted: April 13, 2015" @default.
• W979583005 created "2016-06-24" @default.
• W979583005 creator A5018173206 @default.
• W979583005 creator A5030998201 @default.
• W979583005 creator A5064889179 @default.
• W979583005 date "2015-01-01" @default.
• W979583005 modified "2023-09-24" @default.
• W979583005 title "Calciphylaxis in a Patient With Alcoholic Cirrhosis" @default.
• W979583005 cites W2144976593 @default.
• W979583005 cites W2154960001 @default.
• W979583005 doi "https://doi.org/10.14309/crj.2015.60" @default.
• W979583005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4508942" @default.
• W979583005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26203440" @default.
• W979583005 hasPublicationYear "2015" @default.
• W979583005 type Work @default.
• W979583005 sameAs 979583005 @default.
• W979583005 citedByCount "5" @default.
• W979583005 countsByYear W9795830052017 @default.
• W979583005 countsByYear W9795830052019 @default.
• W979583005 countsByYear W9795830052020 @default.
• W979583005 countsByYear W9795830052023 @default.
• W979583005 crossrefType "journal-article" @default.
• W979583005 hasAuthorship W979583005A5018173206 @default.
• W979583005 hasAuthorship W979583005A5030998201 @default.
• W979583005 hasAuthorship W979583005A5064889179 @default.
• W979583005 hasBestOaLocation W9795830051 @default.
• W979583005 hasConcept C126322002 @default.
• W979583005 hasConcept C141071460 @default.
• W979583005 hasConcept C2775934546 @default.
• W979583005 hasConcept C2776954043 @default.
• W979583005 hasConcept C2777214474 @default.
• W979583005 hasConcept C2778570526 @default.
• W979583005 hasConcept C2779121184 @default.
• W979583005 hasConcept C2780309369 @default.
• W979583005 hasConcept C2780439664 @default.
• W979583005 hasConcept C71924100 @default.
• W979583005 hasConcept C90924648 @default.
• W979583005 hasConceptScore W979583005C126322002 @default.
• W979583005 hasConceptScore W979583005C141071460 @default.
• W979583005 hasConceptScore W979583005C2775934546 @default.
• W979583005 hasConceptScore W979583005C2776954043 @default.
• W979583005 hasConceptScore W979583005C2777214474 @default.
• W979583005 hasConceptScore W979583005C2778570526 @default.
• W979583005 hasConceptScore W979583005C2779121184 @default.
• W979583005 hasConceptScore W979583005C2780309369 @default.
• W979583005 hasConceptScore W979583005C2780439664 @default.
• W979583005 hasConceptScore W979583005C71924100 @default.
• W979583005 hasConceptScore W979583005C90924648 @default.
• W979583005 hasIssue "1" @default.
• W979583005 hasLocation W9795830051 @default.
• W979583005 hasLocation W9795830052 @default.
• W979583005 hasLocation W9795830053 @default.
• W979583005 hasLocation W9795830054 @default.
• W979583005 hasOpenAccess W979583005 @default.
• W979583005 hasPrimaryLocation W9795830051 @default.
• W979583005 hasRelatedWork W2017288711 @default.
• W979583005 hasRelatedWork W2068528440 @default.
• W979583005 hasRelatedWork W2114360645 @default.
• W979583005 hasRelatedWork W2139076554 @default.
• W979583005 hasRelatedWork W2594769977 @default.
• W979583005 hasRelatedWork W3049306923 @default.
• W979583005 hasRelatedWork W3175937464 @default.
• W979583005 hasRelatedWork W4229613766 @default.
• W979583005 hasRelatedWork W4298126437 @default.
• W979583005 hasRelatedWork W979583005 @default.
• W979583005 hasVolume "2" @default.
• W979583005 isParatext "false" @default.
• W979583005 isRetracted "false" @default.
• W979583005 magId "979583005" @default.
• W979583005 workType "article" @default.