FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W97964526> ?p ?o ?g. }

• W97964526 abstract "Chronic rhinosinusitis with nasal polyposis is considered to be a multifactorial disease where different stimuli (mechanical, viral, bacterial, fungal infection, immunological disorders or dysreactivity, environmental pollution), acting on the mucosa of nasal cavities and paranasal sinuses, lead to epithelial damage and mucosal inflammation. Inflammatory cell infiltration (predominantly eosinophils, but also neutrophils, mast cells, macrophages and lymphocytes), cytokine release and sub-epithelial oedema are the histological pictures that are associated, from the clinical point of view, with nasal congestion, secretion and/or post-nasal drip and facial pain/headache. Recently, the importance of the HMG B-1 protein in the pathogenesis of several inflammatory diseases has been demonstrated. This protein is released from necrotic/damaged cells or immune-activated cells, and by acting on specific membrane receptors causes the release of pro-inflammatory mediators, endothelial activation and the survival of inflammatory cells. The objective of the present study was: i) to determine whether HMG B1 is augmented in chronic rhinosinusitis with nasal polyps; ii) if its expression is associated with eosinophils, TNF-α, IL 5 and IL 8 cytokines typically present in chronic inflammation of the nose and paranasal sinuses; iii) to investigate a hypothetical role of this protein in the pathogenesis of nasal polyposis. Nasal polyps tissue from 21 patients affected by CRSwNP and nasal mucosa from 8 controls was collected at the ENT Department of the Chinese PLA General Hospital and underwent immunohistological staining for detection of HMG B1 protein and IL -5, IL -8 and TNF-α inflammatory cytokines. The degree of HMG B1 protein expression was evaluated by dividing the stained sections in 4 portions: 1) nucleus of epithelial cells, 2) cytoplasm of epithelial cells, 3) focal extracellular infiltration, 4) inflammatory cells. HMG B1 was more expressed in the nucleus of epithelial cells of patients compared with controls. In contrast, epithelial cytoplasm HMG B1 staining was significant lower in patients. Sub-epithelial focal infiltration of HMG B1 protein expression was lower in controls, whereas the expression of HMG B1 in the inflammatory cells in patients was significantly increased in comparison with controls. These data, together with the correlation we found between HMG B1 protein expression in different portions and the number of eosinophils infiltrating cells, or IL -5, IL -8 and TNF-α positive cells in patients, suggest that HMG B1 may play a crucial role in the pathogenesis of chronic rhinosinusitis with nasal polyps.RIASSUNTOLa rinosinusite cronica associata o meno a poliposi nasale è considerata una patologia multifattoriale nella quale stimoli di diversa natura (traumi meccanici, infezioni virali, batteriche, fungine, deficit o disreattività immunologica, inquinamento ambientale) agendo sulla mucosa delle cavità nasali e dei seni paranasali ne danneggiano l'epitelio e portano ad infiammazione sub-epiteliale cronica. L'infiltrazione eosinofila, l'espressione di citochine infiammatorie e l'edema sono il corrispettivo istologico del quadro clinico caratterizzato da ostruzione/congestione nasale, secrezione nasale anteriore e posteriore, algie cranio-facciali. Recentemente è stata dimostrata l'importanza della proteina cromosomica HMGB1 nella patogenesi di diverse e numerose patologie infiammatorie; tale proteina viene rilasciata dalle cellule necrotiche/danneggiate o dalle cellule attivate da stimoli immunologici e agendo su specifici recettori di membrana, determina il rilascio di mediatori pro-infiammatori, con richiamo dall'endotelio, attivazione e sopravvivenza di cellule infiammatorie. Obiettivo del presente studio è stato quello di determinare se la proteina HMGB1 è aumentata nella sinusite cronica associata a poliposi nasale; se la sua espressione è associata ad un aumento degli eosinofili, e dell'espressione di IL-5, IL-8 e TNF-α (citochine tipicamente presenti nell'infiammazione cronica dei seni paranasali) al fine di verificare l'ipotesi di un ruolo di questa proteina nella patogenesi della poliposi nasale. Campioni di mucosa naso-sinusale da 21 pazienti affetti da rinosinusite cronica e poliposi nasale e da 8 soggetti di controllo sono stati raccolti presso l'ENT Department del Chinese PLA General Hospital di Pechino e sottoposti a colorazione immunoistochimica per la ricerca della proteina HMGB1 e delle citochine proinfiammatorie IL-5, IL-8, e TNF-α. Il grado di espressione di HMGB1 è stato valutato dividendo le sezioni colorate in 4 porzioni: 1) nucleo delle cellule epiteliali; 2) citoplasma delle cellule epiteliali; 3) infiltrazione extracellulare focale; 4) cellule infiammatorie. HMGB1 è risultata più espressa nel nucleo delle cellule epiteliali dei pazienti rispetto ai controlli. Al contrario la colorazione positiva per HMGB1 nel citoplasma delle cellule epiteliali era meno evidente nei pazienti, così come l'espressione sub-epiteliale focale è risultata meno evidente nei soggetti di controllo. L'espressione di HMGB1 nelle cellule infiammatorie dei pazienti era aumentata in modo significativo rispetto ai controlli. Questi dati, unitamente alla correlazione da noi trovata tra l'espressione di HMGB1 nelle diverse localizzazioni e il numero di eosinofili o di cellule IL-5, IL-8 and TNF-α positive nei pazienti, suggeriscono che HMGB1 possa giocare un ruolo cruciale nella patogenesi della rinosinusite cronica e della poliposi nasale." @default.
• W97964526 created "2016-06-24" @default.
• W97964526 creator A5000799625 @default.
• W97964526 creator A5020268920 @default.
• W97964526 creator A5025436182 @default.
• W97964526 creator A5037023743 @default.
• W97964526 creator A5061643974 @default.
• W97964526 date "2012-12-01" @default.
• W97964526 modified "2023-09-27" @default.
• W97964526 title "The role of High Mobility Group Box 1 chromosomal protein in the pathogenesis of chronic sinusitis and nasal polyposis." @default.
• W97964526 cites W12078422 @default.
• W97964526 cites W140429815 @default.
• W97964526 cites W148711126 @default.
• W97964526 cites W1495991289 @default.
• W97964526 cites W149987944 @default.
• W97964526 cites W17681081 @default.
• W97964526 cites W1885435857 @default.
• W97964526 cites W1968388114 @default.
• W97964526 cites W1999233686 @default.
• W97964526 cites W2004266769 @default.
• W97964526 cites W2004948542 @default.
• W97964526 cites W2018653121 @default.
• W97964526 cites W2091163849 @default.
• W97964526 cites W2097391811 @default.
• W97964526 cites W2109590683 @default.
• W97964526 cites W2140356425 @default.
• W97964526 cites W2143127434 @default.
• W97964526 cites W2147542611 @default.
• W97964526 cites W2414545284 @default.
• W97964526 cites W2993259418 @default.
• W97964526 cites W41934190 @default.
• W97964526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3552540" @default.
• W97964526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23349558" @default.
• W97964526 hasPublicationYear "2012" @default.
• W97964526 type Work @default.
• W97964526 sameAs 97964526 @default.
• W97964526 citedByCount "12" @default.
• W97964526 countsByYear W979645262013 @default.
• W97964526 countsByYear W979645262014 @default.
• W97964526 countsByYear W979645262015 @default.
• W97964526 countsByYear W979645262017 @default.
• W97964526 countsByYear W979645262018 @default.
• W97964526 countsByYear W979645262020 @default.
• W97964526 countsByYear W979645262022 @default.
• W97964526 crossrefType "journal-article" @default.
• W97964526 hasAuthorship W97964526A5000799625 @default.
• W97964526 hasAuthorship W97964526A5020268920 @default.
• W97964526 hasAuthorship W97964526A5025436182 @default.
• W97964526 hasAuthorship W97964526A5037023743 @default.
• W97964526 hasAuthorship W97964526A5061643974 @default.
• W97964526 hasConcept C105702510 @default.
• W97964526 hasConcept C142724271 @default.
• W97964526 hasConcept C164027704 @default.
• W97964526 hasConcept C17991360 @default.
• W97964526 hasConcept C203014093 @default.
• W97964526 hasConcept C2776914184 @default.
• W97964526 hasConcept C2777768476 @default.
• W97964526 hasConcept C2777844070 @default.
• W97964526 hasConcept C2778311950 @default.
• W97964526 hasConcept C2778690821 @default.
• W97964526 hasConcept C2780942790 @default.
• W97964526 hasConcept C2781390199 @default.
• W97964526 hasConcept C59377437 @default.
• W97964526 hasConcept C71924100 @default.
• W97964526 hasConceptScore W97964526C105702510 @default.
• W97964526 hasConceptScore W97964526C142724271 @default.
• W97964526 hasConceptScore W97964526C164027704 @default.
• W97964526 hasConceptScore W97964526C17991360 @default.
• W97964526 hasConceptScore W97964526C203014093 @default.
• W97964526 hasConceptScore W97964526C2776914184 @default.
• W97964526 hasConceptScore W97964526C2777768476 @default.
• W97964526 hasConceptScore W97964526C2777844070 @default.
• W97964526 hasConceptScore W97964526C2778311950 @default.
• W97964526 hasConceptScore W97964526C2778690821 @default.
• W97964526 hasConceptScore W97964526C2780942790 @default.
• W97964526 hasConceptScore W97964526C2781390199 @default.
• W97964526 hasConceptScore W97964526C59377437 @default.
• W97964526 hasConceptScore W97964526C71924100 @default.
• W97964526 hasLocation W979645261 @default.
• W97964526 hasOpenAccess W97964526 @default.
• W97964526 hasPrimaryLocation W979645261 @default.
• W97964526 hasRelatedWork W1505687676 @default.
• W97964526 hasRelatedWork W1568360348 @default.
• W97964526 hasRelatedWork W1934339029 @default.
• W97964526 hasRelatedWork W2003485699 @default.
• W97964526 hasRelatedWork W2027926750 @default.
• W97964526 hasRelatedWork W2039540323 @default.
• W97964526 hasRelatedWork W2093690990 @default.
• W97964526 hasRelatedWork W2100911353 @default.
• W97964526 hasRelatedWork W2102400094 @default.
• W97964526 hasRelatedWork W2111465621 @default.
• W97964526 hasRelatedWork W2154023764 @default.
• W97964526 hasRelatedWork W2164714222 @default.
• W97964526 hasRelatedWork W2733660906 @default.
• W97964526 hasRelatedWork W2776484396 @default.
• W97964526 hasRelatedWork W2889858957 @default.
• W97964526 hasRelatedWork W2993259418 @default.
• W97964526 hasRelatedWork W3042103442 @default.
• W97964526 hasRelatedWork W3046060023 @default.
• W97964526 hasRelatedWork W3169836270 @default.

• next