FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W979844356> ?p ?o ?g. }

• W979844356 abstract "Human hepatic lipase (HL) is an interfacial enzyme that must be liberated from cell surface proteoglycans to hydrolyze lipoprotein triglyceride. HDL and apolipoprotein (apo)A-I can displace HL from cell surface proteoglycans, much like heparin. HL displacement is inhibited by HDL-apoE content. Postprandial HDL is ~2-fold better at displacing HL than fasting HDL, but only has about half the apoE content. Enriching native HDL with triglyceride decreases HDL-apoE content and increases HL displacement. In contrast, enriching synthetic HDL with apoE significantly inhibits HL displacement. HDL from fasted female normolipidemic subjects displaces HL ~2-fold better than HDL from male subjects. HDL from female subjects also has significantly less apoE than HDL from males. Normolipidemic females have increased circulating HDL-bound HL. Hyperlipidemia has little effect on the HL displacement ability of HDL from men, while HDL from hypercholesterolemic females exhibits impaired HL displacement. HL displacement from liver HSPG therefore appears to be linked to interlipoprotein apoE exchange. Decreased HL displacement is associated with higher HDL-apoE levels and may impact vascular triglyceride hydrolysis." @default.
• W979844356 created "2016-06-24" @default.
• W979844356 creator A5087895333 @default.
• W979844356 date "2009-01-01" @default.
• W979844356 modified "2023-09-28" @default.
• W979844356 title "HDL-apoE content regulates the cell surface displacement of hepatic lipase" @default.
• W979844356 cites W113542706 @default.
• W979844356 cites W121664585 @default.
• W979844356 cites W1255346594 @default.
• W979844356 cites W125758503 @default.
• W979844356 cites W1483148680 @default.
• W979844356 cites W1483795916 @default.
• W979844356 cites W1505230657 @default.
• W979844356 cites W1509384892 @default.
• W979844356 cites W1524712279 @default.
• W979844356 cites W1529989543 @default.
• W979844356 cites W1532212223 @default.
• W979844356 cites W1550297117 @default.
• W979844356 cites W1552121180 @default.
• W979844356 cites W1555020435 @default.
• W979844356 cites W1569224973 @default.
• W979844356 cites W1591191431 @default.
• W979844356 cites W1592050530 @default.
• W979844356 cites W1593464696 @default.
• W979844356 cites W1596750278 @default.
• W979844356 cites W1597396112 @default.
• W979844356 cites W1598788587 @default.
• W979844356 cites W1602807170 @default.
• W979844356 cites W1606479506 @default.
• W979844356 cites W16538605 @default.
• W979844356 cites W182198897 @default.
• W979844356 cites W1878775584 @default.
• W979844356 cites W1900613292 @default.
• W979844356 cites W1910284409 @default.
• W979844356 cites W1910326869 @default.
• W979844356 cites W1918638041 @default.
• W979844356 cites W1920171370 @default.
• W979844356 cites W1927538892 @default.
• W979844356 cites W1950519844 @default.
• W979844356 cites W1958197062 @default.
• W979844356 cites W1965277932 @default.
• W979844356 cites W1966594148 @default.
• W979844356 cites W1969050011 @default.
• W979844356 cites W1969070167 @default.
• W979844356 cites W1969913104 @default.
• W979844356 cites W1973268400 @default.
• W979844356 cites W1974778070 @default.
• W979844356 cites W1974988155 @default.
• W979844356 cites W1976132402 @default.
• W979844356 cites W1976559252 @default.
• W979844356 cites W1977832025 @default.
• W979844356 cites W1979386443 @default.
• W979844356 cites W1983340917 @default.
• W979844356 cites W1984135586 @default.
• W979844356 cites W1986439388 @default.
• W979844356 cites W1986967174 @default.
• W979844356 cites W1990252208 @default.
• W979844356 cites W1990455454 @default.
• W979844356 cites W1990815703 @default.
• W979844356 cites W1990847126 @default.
• W979844356 cites W1991128810 @default.
• W979844356 cites W1993409900 @default.
• W979844356 cites W1993613154 @default.
• W979844356 cites W1993819162 @default.
• W979844356 cites W1993881492 @default.
• W979844356 cites W1994096254 @default.
• W979844356 cites W1994509415 @default.
• W979844356 cites W1994618293 @default.
• W979844356 cites W1997849554 @default.
• W979844356 cites W2000356082 @default.
• W979844356 cites W2001758099 @default.
• W979844356 cites W2003854546 @default.
• W979844356 cites W2004906135 @default.
• W979844356 cites W2007697108 @default.
• W979844356 cites W2007831284 @default.
• W979844356 cites W2008418637 @default.
• W979844356 cites W2010710751 @default.
• W979844356 cites W2014409886 @default.
• W979844356 cites W2014646280 @default.
• W979844356 cites W2014766618 @default.
• W979844356 cites W2015132655 @default.
• W979844356 cites W2015139333 @default.
• W979844356 cites W2015809570 @default.
• W979844356 cites W2017203485 @default.
• W979844356 cites W2017305693 @default.
• W979844356 cites W2017443346 @default.
• W979844356 cites W2017531596 @default.
• W979844356 cites W2018018443 @default.
• W979844356 cites W2019074842 @default.
• W979844356 cites W2020661032 @default.
• W979844356 cites W2021446448 @default.
• W979844356 cites W2025764856 @default.
• W979844356 cites W2026856116 @default.
• W979844356 cites W2027927035 @default.
• W979844356 cites W2027967022 @default.
• W979844356 cites W2028556729 @default.
• W979844356 cites W2031423487 @default.
• W979844356 cites W2033399992 @default.
• W979844356 cites W2034968148 @default.
• W979844356 cites W2036362108 @default.

• next