Matches in SemOpenAlex for { <https://semopenalex.org/work/W9801883> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W9801883 endingPage "240" @default.
- W9801883 startingPage "235" @default.
- W9801883 abstract "Fibrates produce additional actions such as reduction of inflammatory state, insulin resistance and activation of blood coagulation, along with stimulation of fibrinolysis. It is not known whether fibrates can attenuate platelet activation.Evaluation of antiplatelet effects of fenofibrate in dyslipidemic subjects.In 20 patients (15 males, 5 females) aged 40 to 70 years who had plasma triglicerydes >1.7 mmol/l and low-density lipoprotein (LDL) cholesterol >3.4 mmol/l without diabetes, we determined plasma levels of platelet markers, soluble CD40 ligand (sCD40L) and selectin P, both in peripheral blood and samples collected every 1 minute from sites of microvascular injury prior to and following a one-month administration of micronized fibrate (160 mg/d). Results. Neither of platelet activation markers was altered following fenofibrate. We identified 7 subjects who had a significant decrease (14-21%) in velocity of the sCD40L and selectin P release after fenofibrate (p < 0.05). This subgroup was characterized by increased body mass, and posttreatment greater reduction in triglycerides and increase in high-density lipoprotein (HDL) cholesterol (p < 0.05). A decrease in the release of platelet markers was associated with a greater posttreatment reduction in plasma 8-isoprostane levels (p = 0.006).In 1/3 of dyslipidemic subjects without diabetes, there is a decrease in platelet activation at the site of microvascular injury following a one-month administration of micronized fenofibrate. This effect can be found in individuals in whom the fibrate induced the greatest reduction in triglycerides and increase in HDL cholesterol. Moreover, antiplatelet effect of fenofibrate was associated with reduced oxidative stress." @default.
- W9801883 created "2016-06-24" @default.
- W9801883 creator A5016533806 @default.
- W9801883 creator A5052251497 @default.
- W9801883 date "2007-05-01" @default.
- W9801883 modified "2023-09-25" @default.
- W9801883 title "Antiplatelet effects of micronized fenofibrate in subjects with dyslipidemia" @default.
- W9801883 cites W1981101682 @default.
- W9801883 cites W2006492339 @default.
- W9801883 cites W2048491412 @default.
- W9801883 cites W2065813468 @default.
- W9801883 cites W2080476072 @default.
- W9801883 cites W2082680963 @default.
- W9801883 cites W2083042102 @default.
- W9801883 cites W2085603223 @default.
- W9801883 cites W2098560324 @default.
- W9801883 cites W2102605113 @default.
- W9801883 cites W2111251212 @default.
- W9801883 cites W2142039559 @default.
- W9801883 cites W2315781349 @default.
- W9801883 cites W2318529542 @default.
- W9801883 doi "https://doi.org/10.20452/pamw.140" @default.
- W9801883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18030873" @default.
- W9801883 hasPublicationYear "2007" @default.
- W9801883 type Work @default.
- W9801883 sameAs 9801883 @default.
- W9801883 citedByCount "2" @default.
- W9801883 countsByYear W98018832014 @default.
- W9801883 countsByYear W98018832021 @default.
- W9801883 crossrefType "journal-article" @default.
- W9801883 hasAuthorship W9801883A5016533806 @default.
- W9801883 hasAuthorship W9801883A5052251497 @default.
- W9801883 hasBestOaLocation W98018832 @default.
- W9801883 hasConcept C126322002 @default.
- W9801883 hasConcept C134018914 @default.
- W9801883 hasConcept C2776933373 @default.
- W9801883 hasConcept C2777391703 @default.
- W9801883 hasConcept C2778096610 @default.
- W9801883 hasConcept C2778110834 @default.
- W9801883 hasConcept C2778163477 @default.
- W9801883 hasConcept C2780072125 @default.
- W9801883 hasConcept C3018697912 @default.
- W9801883 hasConcept C555293320 @default.
- W9801883 hasConcept C71924100 @default.
- W9801883 hasConcept C89560881 @default.
- W9801883 hasConceptScore W9801883C126322002 @default.
- W9801883 hasConceptScore W9801883C134018914 @default.
- W9801883 hasConceptScore W9801883C2776933373 @default.
- W9801883 hasConceptScore W9801883C2777391703 @default.
- W9801883 hasConceptScore W9801883C2778096610 @default.
- W9801883 hasConceptScore W9801883C2778110834 @default.
- W9801883 hasConceptScore W9801883C2778163477 @default.
- W9801883 hasConceptScore W9801883C2780072125 @default.
- W9801883 hasConceptScore W9801883C3018697912 @default.
- W9801883 hasConceptScore W9801883C555293320 @default.
- W9801883 hasConceptScore W9801883C71924100 @default.
- W9801883 hasConceptScore W9801883C89560881 @default.
- W9801883 hasIssue "5-6" @default.
- W9801883 hasLocation W98018831 @default.
- W9801883 hasLocation W98018832 @default.
- W9801883 hasLocation W98018833 @default.
- W9801883 hasLocation W98018834 @default.
- W9801883 hasOpenAccess W9801883 @default.
- W9801883 hasPrimaryLocation W98018831 @default.
- W9801883 hasRelatedWork W2042646534 @default.
- W9801883 hasRelatedWork W2073361868 @default.
- W9801883 hasRelatedWork W2161049361 @default.
- W9801883 hasRelatedWork W2165052328 @default.
- W9801883 hasRelatedWork W2395854128 @default.
- W9801883 hasRelatedWork W2508323870 @default.
- W9801883 hasRelatedWork W2615764640 @default.
- W9801883 hasRelatedWork W2888965340 @default.
- W9801883 hasRelatedWork W2187418944 @default.
- W9801883 hasRelatedWork W30481545 @default.
- W9801883 hasVolume "117" @default.
- W9801883 isParatext "false" @default.
- W9801883 isRetracted "false" @default.
- W9801883 magId "9801883" @default.
- W9801883 workType "article" @default.