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- W980763300 endingPage "189" @default.
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- W980763300 abstract "Chronic infection with hepatitis B virus (HBV) occurs in 6% of the world's population. These carriers of the virus are at high risk for the life-threatening complications of cirrhosis and liver cancer. Although effective vaccines are available to prevent HBV infection, they are of no use to individuals who are already infected with the virus. Therefore, complications of chronic HBV infection are likely to remain a significant public health problem for some time. Stability of the HBV covalently closed circular DNA (cccDNA), together with resistance of this replication intermediate to licensed therapies, are the main reasons for the limited success of currently available treatment interventions. Gene therapy approaches, particularly using exogenous RNA interference (RNAi) activators and derivatives of DNA sequence-specific proteins, have shown potential as HBV therapeutics. Synthetic and expressed RNAi activators have been used successfully to inhibit HBV replication in cell culture and murine models of the infection. A candidate drug comprising a short interfering RNA conjugate is currently in phase II of clinical trial. Although efficacy against the virus is impressive, it remains to be established whether gene silencing will be curative of persistent HBV infection. In one of the first studies using sequence-specific DNA binding proteins, zinc finger proteins (ZFPs) were shown to inhibit transcription from duck HBV cccDNA. Subsequent investigations showed that coupling FokI endonuclease elements to ZFPs or transcription activator-like effectors achieved specific cleavage of HBV DNA, with resultant disabling of viral gene expression. This was an important development in HBV gene therapy because it demonstrated that inactivation of the problematic viral cccDNA replication intermediate is feasible." @default.
- W980763300 created "2016-06-24" @default.
- W980763300 creator A5053685911 @default.
- W980763300 date "2015-01-01" @default.
- W980763300 modified "2023-09-24" @default.
- W980763300 title "Gene Therapy for Chronic Hepatitis B Virus Infection" @default.
- W980763300 cites W1510252058 @default.
- W980763300 cites W1534317756 @default.
- W980763300 cites W1542507443 @default.
- W980763300 cites W1569235975 @default.
- W980763300 cites W1570231448 @default.
- W980763300 cites W1578342120 @default.
- W980763300 cites W1590821429 @default.
- W980763300 cites W1675450733 @default.
- W980763300 cites W1805434135 @default.
- W980763300 cites W1822042631 @default.
- W980763300 cites W1839628956 @default.
- W980763300 cites W1922286450 @default.
- W980763300 cites W1931958712 @default.
- W980763300 cites W1934998482 @default.
- W980763300 cites W1962682498 @default.
- W980763300 cites W1964229627 @default.
- W980763300 cites W1964252228 @default.
- W980763300 cites W1965061107 @default.
- W980763300 cites W1965881016 @default.
- W980763300 cites W1968281475 @default.
- W980763300 cites W1968829868 @default.
- W980763300 cites W1969750903 @default.
- W980763300 cites W1969865366 @default.
- W980763300 cites W1970355156 @default.
- W980763300 cites W1971316234 @default.
- W980763300 cites W1971643509 @default.
- W980763300 cites W1972480731 @default.
- W980763300 cites W1974095602 @default.
- W980763300 cites W1974201337 @default.
- W980763300 cites W1975279384 @default.
- W980763300 cites W1976391205 @default.
- W980763300 cites W1977560219 @default.
- W980763300 cites W1977561926 @default.
- W980763300 cites W1978129709 @default.
- W980763300 cites W1978718906 @default.
- W980763300 cites W1979925053 @default.
- W980763300 cites W1980927876 @default.
- W980763300 cites W1981194036 @default.
- W980763300 cites W1983463907 @default.
- W980763300 cites W1985844740 @default.
- W980763300 cites W1986443131 @default.
- W980763300 cites W1986551392 @default.
- W980763300 cites W1986655312 @default.
- W980763300 cites W1987583940 @default.
- W980763300 cites W1990327182 @default.
- W980763300 cites W1990786614 @default.
- W980763300 cites W1991007428 @default.
- W980763300 cites W1992676108 @default.
- W980763300 cites W1994143142 @default.
- W980763300 cites W1996071244 @default.
- W980763300 cites W1996178608 @default.
- W980763300 cites W1998165633 @default.
- W980763300 cites W1999420933 @default.
- W980763300 cites W2000151960 @default.
- W980763300 cites W2001418979 @default.
- W980763300 cites W2002302294 @default.
- W980763300 cites W2002537198 @default.
- W980763300 cites W2003322056 @default.
- W980763300 cites W2004832653 @default.
- W980763300 cites W2007251666 @default.
- W980763300 cites W2008285918 @default.
- W980763300 cites W2008784634 @default.
- W980763300 cites W2010338556 @default.
- W980763300 cites W2015534632 @default.
- W980763300 cites W2016683820 @default.
- W980763300 cites W2016711065 @default.
- W980763300 cites W2017767695 @default.
- W980763300 cites W2019631541 @default.
- W980763300 cites W2020839898 @default.
- W980763300 cites W2022176220 @default.
- W980763300 cites W2022955650 @default.
- W980763300 cites W2023843484 @default.
- W980763300 cites W2025653108 @default.
- W980763300 cites W2025860397 @default.
- W980763300 cites W2026123650 @default.
- W980763300 cites W2027254129 @default.
- W980763300 cites W2029653860 @default.
- W980763300 cites W2029967774 @default.
- W980763300 cites W2031860444 @default.
- W980763300 cites W2033522034 @default.
- W980763300 cites W2033867130 @default.
- W980763300 cites W2034247538 @default.
- W980763300 cites W2035415258 @default.
- W980763300 cites W2035595979 @default.
- W980763300 cites W2036803556 @default.
- W980763300 cites W2037011892 @default.
- W980763300 cites W2037402545 @default.
- W980763300 cites W2037574032 @default.
- W980763300 cites W2041018831 @default.
- W980763300 cites W2041506786 @default.
- W980763300 cites W2041880635 @default.
- W980763300 cites W2043575899 @default.