FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W9810320> ?p ?o ?g. }

• W9810320 endingPage "670" @default.
• W9810320 startingPage "665" @default.
• W9810320 abstract "The substrate specificity for the transporter that mediates the hepatic uptake of organic anions in freshly isolated hepatocytes of the elasmobranch little skate (Raja erinacea) was determined for bile salts and bile alcohols. The Na(+)-independent transport system exhibits a substrate specificity, which is different from the specificity of Na(+)-dependent bile salt transport in mammals. Unconjugated and conjugated di- and tri-hydroxylated bile salts inhibit uptake of cholyltaurine and cholate competitively. Inhibition is significantly greater with unconjugated as opposed to glycine- or taurine-conjugated bile salts. However, the number of hydroxyl groups in the steroid moiety of the bile salts has only minor influences on the inhibition by the unconjugated bile salts. Since the transport system seems to represent an archaic organic-anion transport system, other anions, such as dicarboxylates, amino acids and sulphate, were also tested, but had no inhibitory effect on bile salt uptake. To clarify whether bile alcohols, the physiological solutes in skate bile, share this transport system, cholyltaurine transport was studied after addition of 5 beta-cholestane-3 beta,5 alpha,6 beta-triol, 5 alpha-cholestan-3 beta-ol and 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol. These bile alcohols inhibit cholyltaurine uptake non-competitively. In contrast, uptake of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol, which is Na(+)-independent, is not inhibited by cholyltaurine. The findings further characterize a Na(+)-independent organic-anion transport system in skate liver cells, which is not shared by bile alcohols and has preference for unconjugated lipophilic bile salts." @default.
• W9810320 created "2016-06-24" @default.
• W9810320 creator A5024106348 @default.
• W9810320 creator A5032676747 @default.
• W9810320 creator A5048480496 @default.
• W9810320 creator A5076629817 @default.
• W9810320 date "1994-05-01" @default.
• W9810320 modified "2023-09-23" @default.
• W9810320 title "Characteristics of bile salt uptake into skate hepatocytes" @default.
• W9810320 cites W1516998764 @default.
• W9810320 cites W1603127702 @default.
• W9810320 cites W1857729996 @default.
• W9810320 cites W1875161787 @default.
• W9810320 cites W1924571493 @default.
• W9810320 cites W1929892270 @default.
• W9810320 cites W1943976550 @default.
• W9810320 cites W1994485942 @default.
• W9810320 cites W1998011451 @default.
• W9810320 cites W2003278647 @default.
• W9810320 cites W2036658784 @default.
• W9810320 cites W2084533194 @default.
• W9810320 cites W2279905842 @default.
• W9810320 cites W2288935177 @default.
• W9810320 cites W2323590715 @default.
• W9810320 cites W2338842431 @default.
• W9810320 cites W2395033401 @default.
• W9810320 cites W2403081554 @default.
• W9810320 cites W2405870895 @default.
• W9810320 cites W2411405018 @default.
• W9810320 cites W2416911638 @default.
• W9810320 cites W2418049140 @default.
• W9810320 cites W2418597082 @default.
• W9810320 cites W2991815803 @default.
• W9810320 doi "https://doi.org/10.1042/bj2990665" @default.
• W9810320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1138072" @default.
• W9810320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8192655" @default.
• W9810320 hasPublicationYear "1994" @default.
• W9810320 type Work @default.
• W9810320 sameAs 9810320 @default.
• W9810320 citedByCount "16" @default.
• W9810320 countsByYear W98103202012 @default.
• W9810320 countsByYear W98103202015 @default.
• W9810320 countsByYear W98103202017 @default.
• W9810320 crossrefType "journal-article" @default.
• W9810320 hasAuthorship W9810320A5024106348 @default.
• W9810320 hasAuthorship W9810320A5032676747 @default.
• W9810320 hasAuthorship W9810320A5048480496 @default.
• W9810320 hasAuthorship W9810320A5076629817 @default.
• W9810320 hasBestOaLocation W98103202 @default.
• W9810320 hasConcept C178790620 @default.
• W9810320 hasConcept C185592680 @default.
• W9810320 hasConcept C18903297 @default.
• W9810320 hasConcept C202751555 @default.
• W9810320 hasConcept C2776200302 @default.
• W9810320 hasConcept C2776371256 @default.
• W9810320 hasConcept C2777289219 @default.
• W9810320 hasConcept C2777756961 @default.
• W9810320 hasConcept C2777769331 @default.
• W9810320 hasConcept C2779399885 @default.
• W9810320 hasConcept C2779701627 @default.
• W9810320 hasConcept C2779853653 @default.
• W9810320 hasConcept C2780480987 @default.
• W9810320 hasConcept C2780902042 @default.
• W9810320 hasConcept C505870484 @default.
• W9810320 hasConcept C515207424 @default.
• W9810320 hasConcept C55493867 @default.
• W9810320 hasConcept C71240020 @default.
• W9810320 hasConcept C71315377 @default.
• W9810320 hasConcept C86803240 @default.
• W9810320 hasConceptScore W9810320C178790620 @default.
• W9810320 hasConceptScore W9810320C185592680 @default.
• W9810320 hasConceptScore W9810320C18903297 @default.
• W9810320 hasConceptScore W9810320C202751555 @default.
• W9810320 hasConceptScore W9810320C2776200302 @default.
• W9810320 hasConceptScore W9810320C2776371256 @default.
• W9810320 hasConceptScore W9810320C2777289219 @default.
• W9810320 hasConceptScore W9810320C2777756961 @default.
• W9810320 hasConceptScore W9810320C2777769331 @default.
• W9810320 hasConceptScore W9810320C2779399885 @default.
• W9810320 hasConceptScore W9810320C2779701627 @default.
• W9810320 hasConceptScore W9810320C2779853653 @default.
• W9810320 hasConceptScore W9810320C2780480987 @default.
• W9810320 hasConceptScore W9810320C2780902042 @default.
• W9810320 hasConceptScore W9810320C505870484 @default.
• W9810320 hasConceptScore W9810320C515207424 @default.
• W9810320 hasConceptScore W9810320C55493867 @default.
• W9810320 hasConceptScore W9810320C71240020 @default.
• W9810320 hasConceptScore W9810320C71315377 @default.
• W9810320 hasConceptScore W9810320C86803240 @default.
• W9810320 hasIssue "3" @default.
• W9810320 hasLocation W98103201 @default.
• W9810320 hasLocation W98103202 @default.
• W9810320 hasLocation W98103203 @default.
• W9810320 hasLocation W98103204 @default.
• W9810320 hasOpenAccess W9810320 @default.
• W9810320 hasPrimaryLocation W98103201 @default.
• W9810320 hasRelatedWork W1964504097 @default.
• W9810320 hasRelatedWork W1973299641 @default.

• next