FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W98119722> ?p ?o ?g. }

• W98119722 endingPage "3975" @default.
• W98119722 startingPage "3963" @default.
• W98119722 abstract "Research Article1 November 1992free access Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest. E.K. Shibuya E.K. Shibuya Department of Anatomy and Cell Biology, Harvard Medical School, Boston, MA 02115. Search for more papers by this author T.G. Boulton T.G. Boulton Department of Anatomy and Cell Biology, Harvard Medical School, Boston, MA 02115. Search for more papers by this author M.H. Cobb M.H. Cobb Department of Anatomy and Cell Biology, Harvard Medical School, Boston, MA 02115. Search for more papers by this author J.V. Ruderman J.V. Ruderman Department of Anatomy and Cell Biology, Harvard Medical School, Boston, MA 02115. Search for more papers by this author E.K. Shibuya E.K. Shibuya Department of Anatomy and Cell Biology, Harvard Medical School, Boston, MA 02115. Search for more papers by this author T.G. Boulton T.G. Boulton Department of Anatomy and Cell Biology, Harvard Medical School, Boston, MA 02115. Search for more papers by this author M.H. Cobb M.H. Cobb Department of Anatomy and Cell Biology, Harvard Medical School, Boston, MA 02115. Search for more papers by this author J.V. Ruderman J.V. Ruderman Department of Anatomy and Cell Biology, Harvard Medical School, Boston, MA 02115. Search for more papers by this author Author Information E.K. Shibuya1, T.G. Boulton1, M.H. Cobb1 and J.V. Ruderman1 1Department of Anatomy and Cell Biology, Harvard Medical School, Boston, MA 02115. The EMBO Journal (1992)11:3963-3975https://doi.org/10.1002/j.1460-2075.1992.tb05490.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Clam oocytes are arrested naturally at the G2/M border in meiosis and contain an inactive 42 kDa ERK/MAP kinase, p42MAPK. Following fertilization, p42MAPK is rapidly phosphorylated on tyrosine residues and concomitantly activated. Both tyrosine phosphorylation and activation of p42MAPK begin within 2–3 min of fertilization, peak at approximately 15 min, then rapidly decline and disappear around the end of meiosis I. Neither the tyrosine phosphorylated form of p42MAPK nor p42MAPK activity reappears during meiosis II or the succeeding mitotic cell cycles. High doses of molybdate, a potent PTPase inhibitor, block the phosphorylation of p42MAPK and entry into the cell cycle. Lower doses of molybdate delay both p42MAPK phosphorylation and the release from cell cycle arrest, but once cells have re-entered the cell cycle, they continue with near-normal timing. These results argue that the transient activation of p42MAPK at fertilization is a one-time event linked to release from cell cycle arrest. In trying to reconcile this one-time activation of p42MAPK in clam embryos with the recurring, M-phase specific activation of MBP/MAP kinases reported in other systems, we show that cdc2 kinase contributes a major portion of the MBP kinase activity in mitotic extracts. Furthermore, a small fraction of p42MAPK and other related kinases are present in p13suc1-bound material, cautioning against the use of p13suc1 beads for experiments where, in addition to cdc2, the unaccounted presence of other kinase activities could be misleading. Previous ArticleNext Article Volume 11Issue 111 November 1992In this issue RelatedDetailsLoading ..." @default.
• W98119722 created "2016-06-24" @default.
• W98119722 creator A5022268890 @default.
• W98119722 creator A5040169264 @default.
• W98119722 creator A5058474480 @default.
• W98119722 creator A5059286276 @default.
• W98119722 date "1992-11-01" @default.
• W98119722 modified "2023-10-16" @default.
• W98119722 title "Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest." @default.
• W98119722 cites W139618738 @default.
• W98119722 cites W1482933775 @default.
• W98119722 cites W1490925016 @default.
• W98119722 cites W1507784087 @default.
• W98119722 cites W1526528713 @default.
• W98119722 cites W1551501779 @default.
• W98119722 cites W1555409791 @default.
• W98119722 cites W1560314955 @default.
• W98119722 cites W1574418401 @default.
• W98119722 cites W1593099788 @default.
• W98119722 cites W1762384317 @default.
• W98119722 cites W1854798937 @default.
• W98119722 cites W1866961404 @default.
• W98119722 cites W1889020465 @default.
• W98119722 cites W1956661481 @default.
• W98119722 cites W1963838671 @default.
• W98119722 cites W1970020870 @default.
• W98119722 cites W1971334343 @default.
• W98119722 cites W1971908328 @default.
• W98119722 cites W1977472414 @default.
• W98119722 cites W1977677084 @default.
• W98119722 cites W1978798502 @default.
• W98119722 cites W1979341555 @default.
• W98119722 cites W1982099849 @default.
• W98119722 cites W1983058690 @default.
• W98119722 cites W1989730199 @default.
• W98119722 cites W1989941131 @default.
• W98119722 cites W1997218197 @default.
• W98119722 cites W2002623358 @default.
• W98119722 cites W2010960436 @default.
• W98119722 cites W2013403124 @default.
• W98119722 cites W2014445311 @default.
• W98119722 cites W2018289835 @default.
• W98119722 cites W2020257412 @default.
• W98119722 cites W2021939146 @default.
• W98119722 cites W2025781389 @default.
• W98119722 cites W2026802787 @default.
• W98119722 cites W2027347011 @default.
• W98119722 cites W2034419242 @default.
• W98119722 cites W2037221816 @default.
• W98119722 cites W2037355625 @default.
• W98119722 cites W2037426608 @default.
• W98119722 cites W2041104433 @default.
• W98119722 cites W2044145281 @default.
• W98119722 cites W2044498188 @default.
• W98119722 cites W2047799300 @default.
• W98119722 cites W2048784760 @default.
• W98119722 cites W2048875557 @default.
• W98119722 cites W2048990794 @default.
• W98119722 cites W2049744804 @default.
• W98119722 cites W2051958366 @default.
• W98119722 cites W2053286013 @default.
• W98119722 cites W2055284107 @default.
• W98119722 cites W2057811505 @default.
• W98119722 cites W2059155490 @default.
• W98119722 cites W2062696392 @default.
• W98119722 cites W2066560193 @default.
• W98119722 cites W2069132844 @default.
• W98119722 cites W2069240478 @default.
• W98119722 cites W2070447958 @default.
• W98119722 cites W2071548379 @default.
• W98119722 cites W2072720547 @default.
• W98119722 cites W2075699262 @default.
• W98119722 cites W2077896046 @default.
• W98119722 cites W2087002482 @default.
• W98119722 cites W2090827556 @default.
• W98119722 cites W2095272722 @default.
• W98119722 cites W2100238612 @default.
• W98119722 cites W2100837269 @default.
• W98119722 cites W2111295274 @default.
• W98119722 cites W2117939247 @default.
• W98119722 cites W2129646494 @default.
• W98119722 cites W2134106883 @default.
• W98119722 cites W2144784260 @default.
• W98119722 cites W2145134793 @default.
• W98119722 cites W2147220557 @default.
• W98119722 cites W2147963427 @default.
• W98119722 cites W2170562004 @default.
• W98119722 cites W2205702781 @default.
• W98119722 cites W2257494122 @default.
• W98119722 cites W2261356028 @default.
• W98119722 cites W2267588421 @default.
• W98119722 cites W2281226559 @default.
• W98119722 cites W2294319944 @default.
• W98119722 cites W2312445582 @default.
• W98119722 cites W2345400668 @default.
• W98119722 cites W2416508542 @default.
• W98119722 cites W41535097 @default.
• W98119722 cites W66625613 @default.

• next