Matches in SemOpenAlex for { <https://semopenalex.org/work/W981215242> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W981215242 endingPage "248" @default.
- W981215242 startingPage "248" @default.
- W981215242 abstract "We read with interest the case of a 69 year old lady who presented clinically with bleeding and ecchimoses [1]. Investigations revealed a prolonged activated partial thromboplastin time (aPTT) at 110.2 s that corrected by 54 % with normal plasma though we are not told to what extent a dilute Russel viper venom time (DRVVT) was prolonged and corrected with hexagonal phospholipids. A factor VIII level was at 04 % (do the authors mean 0.4 or 4.0 %?) and anti-factor VIII level (Bethesda assay) of 08 % (do the authors mean 0.8 or 8.0 %?) with Table 1 showing a complex inhibitor behaviour. The authors have not quoted the thromboplastin used for their aPTT: (1) a lupus insensitive reagent would have been helpful; (2) factor sensitivity to different thromboplastins modulates the correction of the mixing study. In the presence of auto anti-factor VIII antibodies the Bethesda assay may present with a type II inhibitor pattern but LA may interfere with this assay [2]. In the scenario given by the authors a chromogenic FVIII should have been done as well as a FVIII inhibitor measured by immune assay though LA could still interfere with the latter. Likewise, the measurement of anticardiolipin or antibeta-2-glycoprotein-1 antibodies may have better supported the presence of a LA the evidence for which relies on an undisclosed DRVVT [2]. However, a FVIII concentration below 0.15 IU/mL may influence the DRVVT result according to the sensitivity of reagents. While the good clinical response to recombinant factor VII and immune suppression are in keeping with and acquired factor VIII inhibitor, the laboratory diagnosis of factor VIII is poorly supported and that of LA largely inadequate. LA tests based on direct prothrombin activation such as the Textarin/Ecarin [3] or the Taipan/Ecarin ratios [4] are more useful in the presence of factor VIII inhibitor, though not officially incorporated in the LA guidelines [5]." @default.
- W981215242 created "2016-06-24" @default.
- W981215242 creator A5019562652 @default.
- W981215242 creator A5062572601 @default.
- W981215242 creator A5063471956 @default.
- W981215242 date "2015-07-22" @default.
- W981215242 modified "2023-09-26" @default.
- W981215242 title "Co-existent Acquired Haemophilia and Lupus Anticoagulant. A Thorny Issue" @default.
- W981215242 cites W2034232577 @default.
- W981215242 cites W2130225311 @default.
- W981215242 cites W2335762446 @default.
- W981215242 cites W2397505128 @default.
- W981215242 cites W2417920681 @default.
- W981215242 doi "https://doi.org/10.1007/s12288-015-0572-8" @default.
- W981215242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4925514" @default.
- W981215242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27408404" @default.
- W981215242 hasPublicationYear "2015" @default.
- W981215242 type Work @default.
- W981215242 sameAs 981215242 @default.
- W981215242 citedByCount "2" @default.
- W981215242 countsByYear W9812152422017 @default.
- W981215242 countsByYear W9812152422021 @default.
- W981215242 crossrefType "journal-article" @default.
- W981215242 hasAuthorship W981215242A5019562652 @default.
- W981215242 hasAuthorship W981215242A5062572601 @default.
- W981215242 hasAuthorship W981215242A5063471956 @default.
- W981215242 hasBestOaLocation W9812152421 @default.
- W981215242 hasConcept C126322002 @default.
- W981215242 hasConcept C16005928 @default.
- W981215242 hasConcept C177713679 @default.
- W981215242 hasConcept C187212893 @default.
- W981215242 hasConcept C194409129 @default.
- W981215242 hasConcept C198451711 @default.
- W981215242 hasConcept C2776912625 @default.
- W981215242 hasConcept C2778382381 @default.
- W981215242 hasConcept C2778385053 @default.
- W981215242 hasConcept C2779134260 @default.
- W981215242 hasConcept C2780022809 @default.
- W981215242 hasConcept C2780868729 @default.
- W981215242 hasConcept C2910877098 @default.
- W981215242 hasConcept C71924100 @default.
- W981215242 hasConceptScore W981215242C126322002 @default.
- W981215242 hasConceptScore W981215242C16005928 @default.
- W981215242 hasConceptScore W981215242C177713679 @default.
- W981215242 hasConceptScore W981215242C187212893 @default.
- W981215242 hasConceptScore W981215242C194409129 @default.
- W981215242 hasConceptScore W981215242C198451711 @default.
- W981215242 hasConceptScore W981215242C2776912625 @default.
- W981215242 hasConceptScore W981215242C2778382381 @default.
- W981215242 hasConceptScore W981215242C2778385053 @default.
- W981215242 hasConceptScore W981215242C2779134260 @default.
- W981215242 hasConceptScore W981215242C2780022809 @default.
- W981215242 hasConceptScore W981215242C2780868729 @default.
- W981215242 hasConceptScore W981215242C2910877098 @default.
- W981215242 hasConceptScore W981215242C71924100 @default.
- W981215242 hasIssue "S1" @default.
- W981215242 hasLocation W9812152421 @default.
- W981215242 hasLocation W9812152422 @default.
- W981215242 hasLocation W9812152423 @default.
- W981215242 hasLocation W9812152424 @default.
- W981215242 hasOpenAccess W981215242 @default.
- W981215242 hasPrimaryLocation W9812152421 @default.
- W981215242 hasRelatedWork W2048631511 @default.
- W981215242 hasRelatedWork W2064678435 @default.
- W981215242 hasRelatedWork W2084159014 @default.
- W981215242 hasRelatedWork W2085274347 @default.
- W981215242 hasRelatedWork W2111047217 @default.
- W981215242 hasRelatedWork W2125051925 @default.
- W981215242 hasRelatedWork W3088161095 @default.
- W981215242 hasRelatedWork W3113501306 @default.
- W981215242 hasRelatedWork W4322723558 @default.
- W981215242 hasRelatedWork W981215242 @default.
- W981215242 hasVolume "32" @default.
- W981215242 isParatext "false" @default.
- W981215242 isRetracted "false" @default.
- W981215242 magId "981215242" @default.
- W981215242 workType "article" @default.