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- W9820163 abstract "Social rank has been shown to affect sensitivity to cocaine. The present studies examined behavioral and neurochemical measures as predictors of social rank in female cynomolgus monkeys. Sixteen individually housed monkeys were used. Baseline measures of dopamine (DA) transporter (DAT) and D2 receptor availability were obtained using PET (positron emission tomography). In addition, whole blood serotonin (5-HT) (WBS) and measures of 5-HT and DA metabolites (5-HIAA and HVA, respectively) were obtained from cerebrospinal fluid (CSF). Impulsivity was determined by latency to touch a novel, opaque acrylic box placed in their homecage and locomotor activity was assessed in an open-field apparatus. After baseline measures were obtained, monkeys were randomly assigned to four groups of 4 monkeys. Preliminary data (3 of the 4 groups) indicate that baseline levels of DAT and D2 receptor availability, WBS and measures of impulsivity were not predictive of social rank, although there was a trend in latency to approach and touch the novel object, with more impulsive animals (i.e., shorter latencies) becoming subordinate. Significantly higher levels of CSF 5-HIAA were found in the most impulsive animals (p=0.01) which eventually became subordinate and a trend for higher CSF HVA (p=0.053) was seen in subordinate animals. These data document predispositions to social rank related to neurochemical and behavioral measures. DA017763." @default.
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- W9820163 date "2007-01-01" @default.
- W9820163 modified "2023-09-27" @default.
- W9820163 title "Behavioral and neurochemical measures as predictors of social rank in female monkeys" @default.
- W9820163 doi "https://doi.org/10.1096/fasebj.21.6.a1179-b" @default.
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