FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W982204805> ?p ?o ?g. }

• W982204805 endingPage "625" @default.
• W982204805 startingPage "605" @default.
• W982204805 abstract "This chapter reviews the methods used to localize enzyme active sites within the transverse plane of membrane vesicles. Special emphasis is placed on performing appropriate controls and the problems and pitfalls of interpretation are reviewed. The implications of the inferred locations of the enzymes of complex lipid synthesis are discussed and the molecular events of lipid topogenesis are conceptualized. Lipid topogenesis encompasses a diverse series of molecular events beginning with the biosynthesis of the various species of lipids and terminating with the incorporation of each of these lipids in membranes, storage droplets, and secreted lipid products. Early events of lipid topogenesis include the synthesis of complex lipids, the integration of lipids into membranes, and the translocation of lipids across membrane bilayers. Later processes involve intracellular movement of lipids, sorting different classes of lipids from each other to generate membranes and other structures with varying lipid compositions, and the genesis and maintenance of lipid asymmetry within membranes. Topographical localization of the active sites of membrane-bound enzymes within the transverse plane of the membrane requires (1) that the vesicles employed be similarly oriented, (2) that the vesicles be impermeable to the localizing agents, and (3) that the experimental conditions employed do not alter vesicular integrity or orientation. These requirements can be met by taking advantage of the properties of an enzyme or protein that is located on the lumenal surface of the vesicle. In liver microsomes, glucose(mannose)-6-phosphatase has been used as a control for topographical investigations because numerous physical, chemical, immunochemical, and enzymatic studies have established the right-side-out orientation of liver microsomes and the lumenal location of glucose(mannose)-6-phosphatase." @default.
• W982204805 created "2016-06-24" @default.
• W982204805 creator A5021007054 @default.
• W982204805 creator A5031110077 @default.
• W982204805 date "1983-01-01" @default.
• W982204805 modified "2023-09-23" @default.
• W982204805 title "17 Topography of Membrane-Bound Enzymes That Metabolize Complex Lipids" @default.
• W982204805 cites W1487137179 @default.
• W982204805 cites W1492377313 @default.
• W982204805 cites W1510849526 @default.
• W982204805 cites W1526998224 @default.
• W982204805 cites W1527521373 @default.
• W982204805 cites W1530081524 @default.
• W982204805 cites W1550248057 @default.
• W982204805 cites W1557733310 @default.
• W982204805 cites W1583176815 @default.
• W982204805 cites W1909104035 @default.
• W982204805 cites W1942437888 @default.
• W982204805 cites W1970951117 @default.
• W982204805 cites W1971922386 @default.
• W982204805 cites W1975619335 @default.
• W982204805 cites W1977884403 @default.
• W982204805 cites W1982026595 @default.
• W982204805 cites W1989017147 @default.
• W982204805 cites W1998720523 @default.
• W982204805 cites W2001930607 @default.
• W982204805 cites W2003465255 @default.
• W982204805 cites W2006690845 @default.
• W982204805 cites W2008987179 @default.
• W982204805 cites W2009870815 @default.
• W982204805 cites W2016580731 @default.
• W982204805 cites W2019995153 @default.
• W982204805 cites W2020913706 @default.
• W982204805 cites W2022269885 @default.
• W982204805 cites W2030050340 @default.
• W982204805 cites W2030677149 @default.
• W982204805 cites W2033953850 @default.
• W982204805 cites W2035352694 @default.
• W982204805 cites W2044564000 @default.
• W982204805 cites W2047585238 @default.
• W982204805 cites W2050685317 @default.
• W982204805 cites W2051571980 @default.
• W982204805 cites W2053213259 @default.
• W982204805 cites W2056228301 @default.
• W982204805 cites W2056385045 @default.
• W982204805 cites W2056516404 @default.
• W982204805 cites W2057342730 @default.
• W982204805 cites W2058280426 @default.
• W982204805 cites W2060520073 @default.
• W982204805 cites W2063854795 @default.
• W982204805 cites W2071225010 @default.
• W982204805 cites W2072529513 @default.
• W982204805 cites W2072948240 @default.
• W982204805 cites W2083438398 @default.
• W982204805 cites W2086151415 @default.
• W982204805 cites W2086271423 @default.
• W982204805 cites W2087326880 @default.
• W982204805 cites W2089721987 @default.
• W982204805 cites W2094494263 @default.
• W982204805 cites W2128342505 @default.
• W982204805 cites W2129153955 @default.
• W982204805 cites W2132825518 @default.
• W982204805 cites W2134016419 @default.
• W982204805 cites W2134022881 @default.
• W982204805 cites W2147772749 @default.
• W982204805 cites W2149789690 @default.
• W982204805 cites W2159002098 @default.
• W982204805 cites W2178164598 @default.
• W982204805 cites W2178769189 @default.
• W982204805 cites W2180765815 @default.
• W982204805 cites W2181039790 @default.
• W982204805 cites W2337572218 @default.
• W982204805 cites W2412353276 @default.
• W982204805 cites W2413353348 @default.
• W982204805 cites W2413737795 @default.
• W982204805 cites W2416396728 @default.
• W982204805 cites W2422979018 @default.
• W982204805 cites W370870788 @default.
• W982204805 cites W54844821 @default.
• W982204805 cites W63351635 @default.
• W982204805 cites W82150889 @default.
• W982204805 doi "https://doi.org/10.1016/s1874-6047(08)60315-7" @default.
• W982204805 hasPublicationYear "1983" @default.
• W982204805 type Work @default.
• W982204805 sameAs 982204805 @default.
• W982204805 citedByCount "15" @default.
• W982204805 crossrefType "book-chapter" @default.
• W982204805 hasAuthorship W982204805A5021007054 @default.
• W982204805 hasAuthorship W982204805A5031110077 @default.
• W982204805 hasConcept C107565407 @default.
• W982204805 hasConcept C125501631 @default.
• W982204805 hasConcept C12554922 @default.
• W982204805 hasConcept C130316041 @default.
• W982204805 hasConcept C181199279 @default.
• W982204805 hasConcept C185592680 @default.
• W982204805 hasConcept C39944091 @default.
• W982204805 hasConcept C41625074 @default.
• W982204805 hasConcept C55493867 @default.

• next