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- W98231605 abstract "Abstract Induction of antigen-specific tolerance in type 1 diabetes (T1D) to auto-antigens such as the insulin B chain peptide 9-23 (B:9-23) has been proven beneficial when conducted in conjunction with incomplete Freud's adjuvant (IFA) in the NOD (non-obese diabetic) mice. Due to the B:9-23/IFA ongoing clinical trials, the ill-defined mechanisms involved in achieving tolerance after B:9-23/IFA immunization could become a setback for this otherwise attractive T1D prevention strategy. Here we report that a single subcutaneous (s.c.) B:9-23/IFA immunization is as effective at later stages of the disease as at a younger stage, and loses its protective effect after IFNg or IL-10 neutralization but not in the absence of IL-4. Interestingly, when CD4+CD25+ or IFNg-producing cells from B:9-23/IFA protected mice were transferred into pre-diabetic NOD recipients, protection from T1D was conveyed, indicating that a dominant regulatory Treg-mediated effect was operational that depended on IFNg as well as NO production. In agreement, a significant increase in Treg numbers in the spleen and pancreatic draining lymph nodes (PLN) after s.c. B:9-23/IFA immunization was observed. Thus, protection from T1D after s.c. B:9-23/IFA immunization occurs through IFNg/NO and IL-10-mediated suppressive mechanisms." @default.
- W98231605 created "2016-06-24" @default.
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- W98231605 date "2009-04-01" @default.
- W98231605 modified "2023-09-25" @default.
- W98231605 title "Protection from diabetes after subcutaneous insulin B:9-23/IFA immunization is mediated by Tregs that require IL-10, IFNg and NO but not IL-4 (50.39)" @default.
- W98231605 doi "https://doi.org/10.4049/jimmunol.182.supp.50.39" @default.
- W98231605 hasPublicationYear "2009" @default.
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