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- W98242840 endingPage "84" @default.
- W98242840 startingPage "61" @default.
- W98242840 abstract "The formulation scientist’s key goal is to achieve long-term stability of a drug compound. In the case of protein drugs, stabilization means not only maintaining the native chemical structure, but the native secondary and higher order structures necessary for biological activity (Cleland et al., 1993; Manning et al., 1989). Denaturation, as it is defined in this context, will be the process of forming any non-native physical or chemical state of the protein. Physical and chemical denat-urations are often accompanied by covalent and non-covalent aggregates that not only can destroy the activity of the drug, but also cause adverse side effects (Carpenter and Chang, 1996; Thornton and Ballow, 1993). Without the ability to stabilize native protein structures, even the most efficacious protein therapeutics will fail to make viable drug products." @default.
- W98242840 created "2016-06-24" @default.
- W98242840 creator A5027510597 @default.
- W98242840 creator A5052575121 @default.
- W98242840 creator A5063092686 @default.
- W98242840 date "2002-01-01" @default.
- W98242840 modified "2023-10-16" @default.
- W98242840 title "Physical Stabilization of Proteins in Aqueous Solution" @default.
- W98242840 cites W114418772 @default.
- W98242840 cites W1496368635 @default.
- W98242840 cites W1496512127 @default.
- W98242840 cites W1497291976 @default.
- W98242840 cites W1506247487 @default.
- W98242840 cites W1511036913 @default.
- W98242840 cites W1512228649 @default.
- W98242840 cites W1528546831 @default.
- W98242840 cites W1562907760 @default.
- W98242840 cites W157808733 @default.
- W98242840 cites W1605936672 @default.
- W98242840 cites W1879220584 @default.
- W98242840 cites W1965132200 @default.
- W98242840 cites W1965394699 @default.
- W98242840 cites W1968345960 @default.
- W98242840 cites W1968927082 @default.
- W98242840 cites W1970908301 @default.
- W98242840 cites W1970958504 @default.
- W98242840 cites W1974137193 @default.
- W98242840 cites W1980469335 @default.
- W98242840 cites W1980597219 @default.
- W98242840 cites W1981516321 @default.
- W98242840 cites W1982288755 @default.
- W98242840 cites W1985107466 @default.
- W98242840 cites W1986397390 @default.
- W98242840 cites W1988089792 @default.
- W98242840 cites W1991723190 @default.
- W98242840 cites W1992476540 @default.
- W98242840 cites W2001666438 @default.
- W98242840 cites W2003713109 @default.
- W98242840 cites W2006588066 @default.
- W98242840 cites W2007897007 @default.
- W98242840 cites W2017785367 @default.
- W98242840 cites W2019386113 @default.
- W98242840 cites W2024379184 @default.
- W98242840 cites W2026552146 @default.
- W98242840 cites W2027739701 @default.
- W98242840 cites W2029544203 @default.
- W98242840 cites W2032429462 @default.
- W98242840 cites W2035982046 @default.
- W98242840 cites W2040297068 @default.
- W98242840 cites W2041915412 @default.
- W98242840 cites W2045514727 @default.
- W98242840 cites W2050213438 @default.
- W98242840 cites W2050294803 @default.
- W98242840 cites W2050795907 @default.
- W98242840 cites W2051034236 @default.
- W98242840 cites W2053500226 @default.
- W98242840 cites W2055594423 @default.
- W98242840 cites W2056686203 @default.
- W98242840 cites W2057246411 @default.
- W98242840 cites W2061294185 @default.
- W98242840 cites W2061540080 @default.
- W98242840 cites W2062301361 @default.
- W98242840 cites W2066662804 @default.
- W98242840 cites W2067509872 @default.
- W98242840 cites W2070783701 @default.
- W98242840 cites W2072715116 @default.
- W98242840 cites W2072848640 @default.
- W98242840 cites W2078933151 @default.
- W98242840 cites W2079285301 @default.
- W98242840 cites W2082096542 @default.
- W98242840 cites W2086973519 @default.
- W98242840 cites W2088438766 @default.
- W98242840 cites W2089113614 @default.
- W98242840 cites W2094034986 @default.
- W98242840 cites W2114000888 @default.
- W98242840 cites W2118864235 @default.
- W98242840 cites W2119406364 @default.
- W98242840 cites W2125016536 @default.
- W98242840 cites W2135964386 @default.
- W98242840 cites W2141654481 @default.
- W98242840 cites W2151837043 @default.
- W98242840 cites W2156682306 @default.
- W98242840 cites W2161536289 @default.
- W98242840 cites W2200067370 @default.
- W98242840 cites W2217579908 @default.
- W98242840 cites W230984257 @default.
- W98242840 cites W2329952272 @default.
- W98242840 cites W2485000142 @default.
- W98242840 cites W28743847 @default.
- W98242840 cites W2914172929 @default.
- W98242840 cites W4211239749 @default.
- W98242840 cites W4248721956 @default.
- W98242840 cites W5524691 @default.
- W98242840 cites W892297446 @default.
- W98242840 doi "https://doi.org/10.1007/978-1-4615-0557-0_3" @default.
- W98242840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11987754" @default.
- W98242840 hasPublicationYear "2002" @default.
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