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- W98257995 abstract "Publisher Summary This chapter summarizes the dose or exposure component of dose–toxic responses for lead (Pb), presenting the empirical evidence for comparative advantages and limits of various Pb exposure biomarkers. It presents the dose–toxic response relationships for Pb for risk group-specific lead exposures. These relationships are stratified on the basis of affected human risk population subsets, for example, young children, adults, lead workers, and older adults. In addition, individuals within these larger risk categories may be at added differential risk owing to intrinsic factors, such as genetic susceptibilities. The dose–toxic response relationships for environmental lead in humans, taken collectively, produce a picture in which there is not a readily apparent threshold in dose–response terms for the most sensitive toxic endpoints. Dose–toxic response relationships differ with respect to which segments of human populations are affected. Some segments of human populations are much more sensitive to lead contact than others, and these are termed as risk “increased risk,” and “subpopulations.” Given qualitative and quantitative differences across risk populations in terms of dose–responses, these segments are discussed. Each factor defining higher risk is discussed because the basis of differential dose–response relationships in these populations is both exposure driven and toxicology/biology driven." @default.
- W98257995 created "2016-06-24" @default.
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- W98257995 date "2011-01-01" @default.
- W98257995 modified "2023-09-26" @default.
- W98257995 title "Dose–Response Relationships for Toxic Effects of Lead in Human Populations" @default.
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- W98257995 doi "https://doi.org/10.1016/b978-0-444-51554-4.00022-5" @default.
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