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- W98282318 abstract "textabstractCancer is generally feared because it is associated with death and severe physical suffering. Itis one of the most common causes of death in the Netherlands. Breast and colon cancer are themost prevalent types of cancer among women. Frequently occurring types in men are cancer ofcolon, lung and prostate. About 5% of colorectal and breast cancer arises as a result of a mutationin an inherited cancer susceptibility gene. Knowledge about these cancer susceptibility geneshas been accumulating in an impressive manner over the last decades, resulting in the clinicalavailability of genetic testing from the mid-nineties onward.Through genetic testing, an individual’s risk to develop cancer can be determined moreprecisely. This can reduce feelings of uncertainty about the risk one has to develop cancer atsome point in life. Another advantage is that individuals testing negative for the mutation can bedischarged from unnecessary and possibly invasive early detection and/or prevention strategies.Genetic testing has several psychosocial implications, especially for mutation carriers. It impliesknowing to be at high risk to develop cancer at an early stage in life, while often having witnessedthe devastating impact of cancer on close family members. It implies going to hospitals regularlyfor screening with the possibility of hearing bad news, or opting for far-reaching preventiveoptions like prophylactic surgery. It implies that you can pass on or may have passed on thesusceptibility to your own children, who will have to face the same fate. It means that otherclose family members are also at increased risk to develop cancer. Finally, it may imply moredifficulties in obtaining life insurance, mortgage or insurances for disablement.This thesis aims at understanding the psychosocial consequences of genetic susceptibilitytesting for a predisposition to develop breast cancer and colorectal cancer and to identify riskfactors for maladjustment. We focus on individuals from families with a known mutation in theBRCA1 or BRCA2 genes (breast cancer) or one of the HNPCC-related genes (colorectal cancer).The two conditions are comparable according to Rolland’s psychosocial typology1 with regardto the likelihood of developing cancer, the timing of clinical onset in life cycle, overall clinicalseverity and availability of prevention and treatment options." @default.
- W98282318 created "2016-06-24" @default.
- W98282318 creator A5085355195 @default.
- W98282318 date "2006-12-13" @default.
- W98282318 modified "2023-09-27" @default.
- W98282318 title "Family Matters: Adjustment to genetic cancer susceptibility testing" @default.
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