Matches in SemOpenAlex for { <https://semopenalex.org/work/W982830523> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W982830523 endingPage "50.31" @default.
- W982830523 startingPage "50.31" @default.
- W982830523 abstract "Abstract Tissue fibrosis is a major cause of morbidity and mortality in systemic sclerosis (SSc). TGF-β is well known to be the principal factor that leads to tissue fibrosis. We tested a novel small compound HSc025, which is an antagonist of TGF-β/Smads signaling, would prevent tissue fibrosis in vitro or in mouse models of SSc. Human dermal fibroblasts were exposed at various doses of HSc025 in the presence of TGF-β, and the expression levels of collagen or fibronectin were determined. Administration of HSc025 (15 mg/kg/day, p.o.), halofuginone (1μg/mouse/day, i.p.) or placebo to tight skin mouse or to bleomycin-induced pulmonary fibrosis mice was performed for 14 days. Pretreatment with HSc025 prevented Smad-dependent promoter activation in a dose-dependent manner, however, HSc025 had no effect on TGF-β-induced phosphorylation of Smad3. The inhibitory effects of HSc025 on TGF-β-induced collagen or fibronectin expression were also confirmed in vitro. The oral administration of HSc025 dramatically reduced hypodermal thickness in tight skin mice, and markedly decreased hydroxyproline contents and histological score in the lungs of bleomycine-treated mice. These results demonstrate that HSc025 is a novel inhibitor against TGF-β/Smads signaling, resulting in the improvement of skin and pulmonary fibrosis. Therefore, orally available HSc025 might be useful for the therapy of SSc." @default.
- W982830523 created "2016-06-24" @default.
- W982830523 creator A5001162086 @default.
- W982830523 creator A5003342014 @default.
- W982830523 creator A5005434082 @default.
- W982830523 creator A5042842517 @default.
- W982830523 creator A5045059471 @default.
- W982830523 creator A5045391986 @default.
- W982830523 creator A5064648891 @default.
- W982830523 creator A5076516028 @default.
- W982830523 date "2009-04-01" @default.
- W982830523 modified "2023-09-25" @default.
- W982830523 title "A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in model mice of systemic sclerosis (50.31)" @default.
- W982830523 doi "https://doi.org/10.4049/jimmunol.182.supp.50.31" @default.
- W982830523 hasPublicationYear "2009" @default.
- W982830523 type Work @default.
- W982830523 sameAs 982830523 @default.
- W982830523 citedByCount "0" @default.
- W982830523 crossrefType "journal-article" @default.
- W982830523 hasAuthorship W982830523A5001162086 @default.
- W982830523 hasAuthorship W982830523A5003342014 @default.
- W982830523 hasAuthorship W982830523A5005434082 @default.
- W982830523 hasAuthorship W982830523A5042842517 @default.
- W982830523 hasAuthorship W982830523A5045059471 @default.
- W982830523 hasAuthorship W982830523A5045391986 @default.
- W982830523 hasAuthorship W982830523A5064648891 @default.
- W982830523 hasAuthorship W982830523A5076516028 @default.
- W982830523 hasConcept C118131993 @default.
- W982830523 hasConcept C126322002 @default.
- W982830523 hasConcept C134018914 @default.
- W982830523 hasConcept C150903083 @default.
- W982830523 hasConcept C185592680 @default.
- W982830523 hasConcept C189165786 @default.
- W982830523 hasConcept C207001950 @default.
- W982830523 hasConcept C2776232574 @default.
- W982830523 hasConcept C2776694085 @default.
- W982830523 hasConcept C2779797417 @default.
- W982830523 hasConcept C2780559512 @default.
- W982830523 hasConcept C2781080636 @default.
- W982830523 hasConcept C2781244666 @default.
- W982830523 hasConcept C502942594 @default.
- W982830523 hasConcept C55493867 @default.
- W982830523 hasConcept C71924100 @default.
- W982830523 hasConcept C86492073 @default.
- W982830523 hasConcept C86803240 @default.
- W982830523 hasConcept C98274493 @default.
- W982830523 hasConceptScore W982830523C118131993 @default.
- W982830523 hasConceptScore W982830523C126322002 @default.
- W982830523 hasConceptScore W982830523C134018914 @default.
- W982830523 hasConceptScore W982830523C150903083 @default.
- W982830523 hasConceptScore W982830523C185592680 @default.
- W982830523 hasConceptScore W982830523C189165786 @default.
- W982830523 hasConceptScore W982830523C207001950 @default.
- W982830523 hasConceptScore W982830523C2776232574 @default.
- W982830523 hasConceptScore W982830523C2776694085 @default.
- W982830523 hasConceptScore W982830523C2779797417 @default.
- W982830523 hasConceptScore W982830523C2780559512 @default.
- W982830523 hasConceptScore W982830523C2781080636 @default.
- W982830523 hasConceptScore W982830523C2781244666 @default.
- W982830523 hasConceptScore W982830523C502942594 @default.
- W982830523 hasConceptScore W982830523C55493867 @default.
- W982830523 hasConceptScore W982830523C71924100 @default.
- W982830523 hasConceptScore W982830523C86492073 @default.
- W982830523 hasConceptScore W982830523C86803240 @default.
- W982830523 hasConceptScore W982830523C98274493 @default.
- W982830523 hasIssue "1_Supplement" @default.
- W982830523 hasLocation W9828305231 @default.
- W982830523 hasOpenAccess W982830523 @default.
- W982830523 hasPrimaryLocation W9828305231 @default.
- W982830523 hasRelatedWork W1980904518 @default.
- W982830523 hasRelatedWork W2049039465 @default.
- W982830523 hasRelatedWork W2102239057 @default.
- W982830523 hasRelatedWork W2372247065 @default.
- W982830523 hasRelatedWork W2375904247 @default.
- W982830523 hasRelatedWork W2391499467 @default.
- W982830523 hasRelatedWork W2963945351 @default.
- W982830523 hasRelatedWork W2997650434 @default.
- W982830523 hasRelatedWork W3029119157 @default.
- W982830523 hasRelatedWork W982830523 @default.
- W982830523 hasVolume "182" @default.
- W982830523 isParatext "false" @default.
- W982830523 isRetracted "false" @default.
- W982830523 magId "982830523" @default.
- W982830523 workType "article" @default.