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- W982890729 abstract "This chapter summarizes the significant advances in the knowledge of the biosynthesis and neurophysiology of endorphins, and the increased intensity of research stimulated by the discovery and characterization of the endorphins. Recent evidence supports the existence of two separate opioid receptor systems in brain, using a combination of anatomical, biochemical, and immunological methods, several groups have differentiated enkephalin neuronal systems from β-LPH/β-endorphin/ ACTH positive systems. It has been shown that aminopeptidase-induced enkephalin degradation proceeds at the same rate whether or not the peptide is bound to its receptors. It is suggested that this effect is because of the inhibition of endogenous enkephalin or endorphin metabolism. It is found that endorphins induce a range of cardiovascular effects. The reversal of endotoxin-induced hypotension by naloxone implies that endorphins may have a role in the physiology of shock. Both met-enkephalin and morphine have been shown to increase histamine-induced gastric secretion and gastric mucosal blood flow and to inhibit induced pancreatic bicarbonate secretion in dogs. The reversal of these effects by naloxone suggests a mechanism involving opioid receptors. It has been found that morphine and β-endorphin exert similar effects on the nuendocnrine pancreas. These results indicate the presence of opioid receptors on the islets of Langerhans. The hypothesis that acupuncture produces analgesia through the release of endorphins has received much attention. Since the discovery of the endorphins, there has been much speculation concerning their significance in psychiatric disorders.D-Ala2, N-MeMet -enkephalinamide has been found to be a potent parenteral analgesic. Structure–activity studies with enkephalin analogs have provided support for the hypothesis that analgesia is mediated by the μ-receptor. An aryloxazine derivative is reported to be more potent than morphine in the hot plate and phenylquinone writhing tests, and about equipotent with morphine in blocking acetic acid writhing." @default.
- W982890729 created "2016-06-24" @default.
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- W982890729 date "1979-01-01" @default.
- W982890729 modified "2023-09-23" @default.
- W982890729 title "Chapter 4 Analgetics, Endorphins and the Opioid Receptor" @default.
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- W982890729 doi "https://doi.org/10.1016/s0065-7743(08)61349-4" @default.
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