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- W98334189 abstract "Insulin like growth factor system becomes impaired in liver cirrhosis. Hepatocellular carcinoma (HCC) is associated with altered synthesis and secretion of several growth factors.Studying the relation between serum levels of IGF-I, IGF-II and IGFBP-3 and clinical grades of liver disease according to Child-Pugh (C-P) score. Also, evaluation of their role in the diagnosis of HCC. IGF-I, IGF-II and IGFBP-3 were measured in 20 healthy subjects, 60 liver cirrhosis patients and 20 HCC patients included in the study.IGF-I, IGF-II and IGFBP-3 levels were significantly lower in cirrhotic patients compared to the healthy subjects and were correlated with the degree of liver dysfunction. IGF-I and IGFBP-3 levels in patients with HCC were significantly lower than in both healthy subjects and in patients with liver cirrhosis. Both IGF-II and AFP levels in HCC were significantly higher than in healthy subjects and in patients with liver cirrhosis.Estimation of serum IGF-I, IGF-II and IGFBP-3 together with C-P score is more effective in predicting hepatic dysfunction and its severity than C-P score alone. Serum IGF-II level can be used as a serological marker to discriminate HCC from cirrhosis." @default.
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- W98334189 date "2011-08-13" @default.
- W98334189 modified "2023-09-29" @default.
- W98334189 title "Serum IGF-1, IGF-2 and IGFBP-3 as parameters in the assessment of liver dysfunction in patients with hepatic cirrhosis and in the diagnosis of hepatocellular carcinoma." @default.
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