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- W983498118 abstract "The high rate of loss of the penicillinase genes from Staphylococcus aureus suggests that these genes are not carried as part of the bacterial chromosome but are present on an extrachromosomal piece of DNA, commonly called as a “plasmid.” Penicillinase plasmids of S. aureus exhibit similarity in certain respects to the episomes of the enterobacteria. The conclusion as to whether a gene is chromosomal or extrachromosomal on the basis of its sensitivity to ultraviolet radiation when undergoing transduction is based on Arber's experiments, concerning the transduction of genetic markers between E. coli strains using phage P1. The most convincing evidence that experiments of the Arber type indicate an extrachromosomal location in S. aureus, comes from a study of strain PS80. This strain is resistant to tetracycline and to mercury salts and synthesizes penicillinase. The evidence suggests, prima facie, that the mercury and tetracycline genes are carried on separate plasmids, while the penicillinase gene is chromosomal. A number of different types of penicillinase plasmid are identified on the basis of the genetic determinants they carry. The markers that are present in the plasmid state in S. aureus include: (1) penicillinase region, (2) extracellularity region (exo), (3) erythromycin resistance (eroR), (4) resistance to mercury salts (HgR), (5) resistance to cadmium salts (CdR), and (6) resistance to arsenate (AsaR) and arsenite (AsiR) ions." @default.
- W983498118 created "2016-06-24" @default.
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- W983498118 date "1968-01-01" @default.
- W983498118 modified "2023-09-25" @default.
- W983498118 title "The Plasmids of Staphylococcus aureus and their Relation to Other Extrachromosomal Elements in Bacteria" @default.
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- W983498118 doi "https://doi.org/10.1016/s0065-2911(08)60259-3" @default.
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