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- W984046438 abstract "[Objective] To investigate the effect of polyphenol phytochemicals in echinacea on stress gastric ulcer in rats under restraint water-immersion stress.[Methods] Fifty healthy SD rats(equal male and female) were randomly divided into five groups,which were control group with cimetidine,control group with normal saline(NS),rhodioloside group and echinacea extract group under restraint water stress.Ulcer index,spleen index,and nitric oxide synthase(NOS) activity of gastric mucosa were measured.[Results] The ulcer index(UI) of echinacea extract group was(15±2) score,compared with UI(65±4) score of NS model group,there was a statistically significant decrease between them(P0.01).The spleen index(SI) of echinacea extract group was(5.425±0.548),compared with SI(2.323±0.392) of NS model group,there was a statistically significant increase between them(P0.01).Otherwise,the NOS activity of gastric mucosa in glandular stomach and the body of stomach were(56.249±3.473) U/mgprot and(53.852±6.146) U/mgprot respectively,compared with NS model group(28.240±4.956) U/mgprot and(27.173±4.244) U/mgprot,there was a statistically significant increase between them(P0.01).[Conclusion] Polyphenol phytochemicals in echinacea may prevent the gastric mucosal damage from stress in rats by improving their immunity,coordinating and increasing the activity of NOS." @default.
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- W984046438 date "2009-01-01" @default.
- W984046438 modified "2023-09-26" @default.
- W984046438 title "Effect of polyphenol phytochemicals in echinacea on stress gastric ulcer in rats." @default.
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