Matches in SemOpenAlex for { <https://semopenalex.org/work/W984501295> ?p ?o ?g. }
- W984501295 abstract "Publisher Summary This chapter illustrates distribution and metabolism of drugs in the lungs, the relationship of drug metabolism and disposition to safety, drug interactions, hepatic esterases and amidases, metabolic factors in liver toxicity, hemodynamic factors in drug disposition, and the blood–brain barrier. The fact that metabolic events frequently lead to active or toxic metabolites merits consideration by the medicinal chemist as does information on new or little studied biotransformation routes. Species differences in drug metabolism are also addressed because they bear directly on the relevance of efficacy and toxicity observed in animals to usefulness in man. Drug metabolism studies are of greatest value to the drug discovery process when they are carried out early and permit rapid feedback to the synthetic program. The frequency with which the toxicity of drugs and other chemicals is mediated by metabolism and covalent binding of a reactive species to tissue macromolecules has stimulated considerable study of the biotransformation of a number of new and important agents. Increasing evidences suggest that intermediate epoxide formation is an important metabolic transformation of xenobiotics that contain an aromatic or olefinic double bond. The recognition that metabolism may vary with the species employed is important for the extrapolation of animal data to man. The problems and considerations involved in the selection of appropriate species for toxicology and drug metabolism studies have been pointed in the chapter." @default.
- W984501295 created "2016-06-24" @default.
- W984501295 creator A5039148683 @default.
- W984501295 creator A5083536003 @default.
- W984501295 date "1976-01-01" @default.
- W984501295 modified "2023-09-24" @default.
- W984501295 title "Chapter 20: Drug Metabolism" @default.
- W984501295 cites W1605194916 @default.
- W984501295 cites W167047154 @default.
- W984501295 cites W1790064321 @default.
- W984501295 cites W1806027788 @default.
- W984501295 cites W183238076 @default.
- W984501295 cites W1968129329 @default.
- W984501295 cites W1981739423 @default.
- W984501295 cites W1991960566 @default.
- W984501295 cites W1996546122 @default.
- W984501295 cites W1997473454 @default.
- W984501295 cites W2000997391 @default.
- W984501295 cites W2001336191 @default.
- W984501295 cites W2005137568 @default.
- W984501295 cites W2005650649 @default.
- W984501295 cites W2007249568 @default.
- W984501295 cites W2008498154 @default.
- W984501295 cites W2009258381 @default.
- W984501295 cites W2009655736 @default.
- W984501295 cites W2010481248 @default.
- W984501295 cites W2013001212 @default.
- W984501295 cites W2015720516 @default.
- W984501295 cites W2016421907 @default.
- W984501295 cites W2017126941 @default.
- W984501295 cites W2020202746 @default.
- W984501295 cites W2020530329 @default.
- W984501295 cites W2023253697 @default.
- W984501295 cites W2025085241 @default.
- W984501295 cites W2030602439 @default.
- W984501295 cites W2030802138 @default.
- W984501295 cites W2030833170 @default.
- W984501295 cites W2034440394 @default.
- W984501295 cites W2037378217 @default.
- W984501295 cites W2039510854 @default.
- W984501295 cites W2040016958 @default.
- W984501295 cites W2040397099 @default.
- W984501295 cites W2041699982 @default.
- W984501295 cites W2041896439 @default.
- W984501295 cites W2041968020 @default.
- W984501295 cites W2043038230 @default.
- W984501295 cites W2043158799 @default.
- W984501295 cites W2049812547 @default.
- W984501295 cites W2051344162 @default.
- W984501295 cites W2051826669 @default.
- W984501295 cites W2053519145 @default.
- W984501295 cites W2054772612 @default.
- W984501295 cites W2062424211 @default.
- W984501295 cites W2063541665 @default.
- W984501295 cites W2064850461 @default.
- W984501295 cites W2067956802 @default.
- W984501295 cites W2067968484 @default.
- W984501295 cites W2072482644 @default.
- W984501295 cites W2073891662 @default.
- W984501295 cites W2082300992 @default.
- W984501295 cites W2084300131 @default.
- W984501295 cites W2087328181 @default.
- W984501295 cites W2088614490 @default.
- W984501295 cites W2091264029 @default.
- W984501295 cites W2128818892 @default.
- W984501295 cites W2128890618 @default.
- W984501295 cites W2147924039 @default.
- W984501295 cites W2152416963 @default.
- W984501295 cites W2173347944 @default.
- W984501295 cites W2176174715 @default.
- W984501295 cites W2205439823 @default.
- W984501295 cites W2207703493 @default.
- W984501295 cites W2213501008 @default.
- W984501295 cites W2227857458 @default.
- W984501295 cites W2232615845 @default.
- W984501295 cites W2241942658 @default.
- W984501295 cites W2245055231 @default.
- W984501295 cites W2258032401 @default.
- W984501295 cites W2269390252 @default.
- W984501295 cites W2287920202 @default.
- W984501295 cites W2337542599 @default.
- W984501295 cites W2340394264 @default.
- W984501295 cites W2341080496 @default.
- W984501295 cites W2346582185 @default.
- W984501295 cites W2398675547 @default.
- W984501295 cites W2401910378 @default.
- W984501295 cites W2405064386 @default.
- W984501295 cites W2405163904 @default.
- W984501295 cites W2411454505 @default.
- W984501295 cites W2416044448 @default.
- W984501295 cites W2416505483 @default.
- W984501295 cites W2417322201 @default.
- W984501295 cites W2419084010 @default.
- W984501295 cites W2430583035 @default.
- W984501295 cites W2444300926 @default.
- W984501295 cites W2523411952 @default.
- W984501295 cites W2531586095 @default.
- W984501295 cites W591241457 @default.
- W984501295 cites W94037854 @default.
- W984501295 cites W1861490824 @default.