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- W984890302 abstract "There has been substantial progress in the imaging of dopamine transporters. The earliest positron emission tomography (PET) experiments used carbon-11 labeled nominfensine (1,44); whereas recent investigations by both PET and single photon emission computed tomography (SPECT) utilize a variety of ligands with a variety of properties and address many biological questions (see below). The earliest ligands utilized, [11C]nomifensine and [11C]cocaine, were somewhat limited because of low signal-to-noise ratios. Nevertheless, [11C]cocaine as a ligand continues to be popular, because it is the same authentic substance that is abused around the world. The best, current 3-substituted phenyltropane ligands, such as RTI-55, have vastly improved signal-to-noise ratios. These successes are in no small part because of the development of the chemistry of cocaine analogs and other analogs of inhibitors for transporters (Fig. 1) (4,8). Despite this progress, several important things remain to be achieved. We need to develop methods to carry out rigorous calculations of Bmax instead of relying on more inexact but easier measures of relative occupancy and binding potential. We also need useful ligands for all transporters in brain." @default.
- W984890302 created "2016-06-24" @default.
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- W984890302 date "1997-01-01" @default.
- W984890302 modified "2023-09-27" @default.
- W984890302 title "Imaging Transporters for Dopamine and Other Neurotransmitters in Brain" @default.
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- W984890302 doi "https://doi.org/10.1007/978-1-59259-470-2_10" @default.
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