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• W984911366 startingPage "113" @default.
• W984911366 abstract "Bacterial genomes are usually packed with genes occupying around 90% of their DNA, and no structures resembling isochores or telomeres have been identified. A second source of heterogeneity could come from structural domains in the genome, which would make some areas of the chromosome more accessible than others to foreign DNA sequences and influence intrachromosomal recombination. With the advent of genomic data and the improvement of methods for replication origin and terminus detection, it is now possible to review the genome balance hypothesis. The mutation probability has been proposed to vary within a bacterial chromosome for genes located at different positions relative to the replication origin. Electron micrographs of the Escherichia coli chromosome displayed a rossette-like organization with loops of supercoiled DNA distributed around a central node. Species such as Staphylococcus aureus and E. coli display an increase in horizontally acquired genes closer to the terminus, whereas transposable elements seem unaffected. Sequence repeats, in all their variants, are one of the main evolutionary tools to generate variability, this being structural (rearrangements) or functional (generation of new genes). The plethora of genomic data has unexpectedly suggested that the traditional view of IS Elements (ISs) as detrimental selfish elements is probably an oversimplification. In relation to bacterial pathogens, the data suggest that their genomes are more flexible than related nonpathogenic species, as if their need for fast adaptation and plasticity had relaxed organizational constraints." @default.
• W984911366 created "2016-06-24" @default.
• W984911366 creator A5034956032 @default.
• W984911366 creator A5045838421 @default.
• W984911366 date "2014-04-30" @default.
• W984911366 modified "2023-09-23" @default.
• W984911366 title "Genome Architecture and Evolution of Bacterial Pathogens" @default.
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