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- W9849609 abstract "Mathematical tools have been applied to evaluate the autonomic balance. In particularly, it is widely used the fast Fourier transformer (FFT) that is able to produce a power spectrum of the frequencies from a stationary signal. Nucleus tractus solitarius (NTS) is an important area in the central regulation of autonomic functions. In ethanol addiction, there is an imbalance of autonomic flow but its underlying mechanisms are poorly understood. The purpose of the present study was to investigate the cardiorespiratory responses on acute ethanol application in the NTS and its intravenous administration in normal rats and in a rat model of chronic ethanol consumption (EtOH rats), evaluating, in both conditions, the autonomic balance using a new mathematical tool - wavelets method. Mean arterial blood pressure (MBP), ECG, heart rate (HR) and phrenic nerve activity were monitored. Results show a decrease of all the recorded variables both on normal and addict rats for the moderate ethanol doses applied to the NTS; on intravenous administration of ethanol no changes were observed in cardiorespiratory variables. On evaluation of autonomic nervous system using wavelet method, EtOH rats revealed an elevated sympathetic component in comparison with the normal rats. After i.v. administration of ethanol, an increase on the sympathetic mediated component of normal rats was seen by opposition to the decrease of this component observed in EtOH rats. These results suggest the presence of a neuroadaptation elicited to counteract the autonomic imbalance evoked by ethanol addiction. The wavelet method showed to be a good way of evaluating the transient modification of biological signals." @default.
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- W9849609 date "2004-01-01" @default.
- W9849609 modified "2023-09-27" @default.
- W9849609 title "SPECTRAL EVALUATION OF AUTONOMIC CHANGES PRODUCED BY CHRONIC ETHANOL ADMINISTRATION IN RATS" @default.
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