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- W984964308 abstract "This chapter describes both established and experimental anti-ulcer drugs from plants and attempts to relate structural features in active compounds to the pathology of peptic ulceration. Plants provide an alternative strategy in the search for new drugs. The exploitation of the old herbal books led to the discovery of the first modern anti-ulcer drug—carbenoxolone. Despite this early success, plants are still largely unexploited as sources of new drugs. Medicinal plants offer the chemist and the pharmacologist a rich source of new molecules to explore as future drugs or as biochemical tools to unravel aetiology. Many medicinal plants listed in ancient pharmacopoeias have a reputation for treating gastric disorders. Crude drugs derived from such plants contain only low concentrations of active substances and in consequence are often largely ineffective. Before considering the mode of action of carbenoxolone sodium, it is necessary to understand the pathology of peptic ulcer formation. Peptic ulcer is a convenient term that covers both gastric and duodenal ulcers. An examination of the phytochemical literature for anti-ulcer molecules reveals that anti-ulcer activity is not confined to one class of compound. Such activity is usually discovered by screening various plant molecules against one or more animal models. Biochemical information on the role of plant drugs in preventing ulceration is of increasing importance." @default.
- W984964308 created "2016-06-24" @default.
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- W984964308 date "1991-01-01" @default.
- W984964308 modified "2023-10-14" @default.
- W984964308 title "4 Anti-Ulcer Drugs of Plant Origin" @default.
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- W984964308 doi "https://doi.org/10.1016/s0079-6468(08)70365-5" @default.
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