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- W985524434 abstract "Publisher Summary This chapter describes the antineutrophil cytoplasmic antibodies (ANCA) in inflammatory bowel diseases (IBD). To identify the nature of P-ANCA antigen recognition, P-ANCA sensitivity to DNase treatment was compared among patients with ulcerative colitis and other P-ANCA-expressing diseases (primary sclerosing cholangitis, type 1 autoimmune hepatitis). These experiments showed a loss of antigenic recognition after DNase digestion of neutrophils. The existence of subgroups of pathogenically distinct inflammatory bowel diseases, if confirmed by subclinical (genetic and/or immunologic markers) and clinical markers, might permit tailored therapeutic regimens, targeted at selected points in the pathogenic process. Genetic and subclinical marker studies of ulcerative colitis and Crohn's disease will continue to elucidate the ongoing puzzles of disease manifestation and diagnosis. In inflammatory bowel diseases, standard therapy is directed against the final stages of nonspecific inflammation. The treatment does not alter the natural history of relapse and remission of the disease and is based predominantly on anti-inflammatory properties." @default.
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- W985524434 date "1996-01-01" @default.
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- W985524434 title "Antineutrophil Cytoplasmic Antibodies in Inflammatory Bowel Diseases" @default.
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- W985524434 doi "https://doi.org/10.1016/b978-044482383-0/50009-1" @default.
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