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- W985575737 abstract "α- Fetoprotein (AFP) is one of the most thoroughly characterized oncodevelopmental proteins. The salient features of the characteristics and expression of AFP are summarized in the chapter. The immunochemical properties and assay of AFP are also discussed. AFP was first detected by paper electrophoresis of fetal serum and it was detected, quantitated, and even purified using antibodies. AFP is strongly immunogenic when injected into a foreign species but does not elicit an immune response in the species of origin. With most globular proteins, the antigenicity of AFP seems to depend on the 3D conformation of the polypeptide chain. Human AFP unfolded by reduction in urea loses its inhibitory activity in the usual immunoassays. The concentration of AFP in fetal serum is in the range of milligrams per milliliter, and it usually gives rise to production of antibodies, even in an admixture with other fetal serum proteins. In most species, AFP is the only fetal serum protein present in appreciable quantities that is not shared by the adult serum. AFP has a well-established position as a diagnostic tool in the diagnosis and follow-up of liver cancer and germ cell tumors. It is also extremely useful in the early prenatal diagnosis of fetal anomalies, such as neural tube malformations and congenital nephrosis. As a well-characterized protein, AFP provides an important model system in the studies of the phenomena associated with gene expression." @default.
- W985575737 created "2016-06-24" @default.
- W985575737 creator A5056382994 @default.
- W985575737 creator A5088477154 @default.
- W985575737 date "1979-01-01" @default.
- W985575737 modified "2023-10-16" @default.
- W985575737 title "α-Fetoprotein in Cancer and Fetal Development" @default.
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