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- W985596590 abstract "Objective The study is designed to investigate the effect by NEP1-40 on Nogo A in high phenyalanine (Phe) in vitro. Methods Cells was dissected from the cerebral cortex of E16~E18 embryos of SD rat. Real-time PCR and Western blot were used to quantify mRNA and protein of Nogo A respectively. The growth cones, axon and the Nogo A location were performed by immunofluorescence and immunohistochemistry respectively. Results Compared to the control, the mRNA and protein level of Nogo A with Phe for 12 h, 24 h and 48 h were slightly reduced. NEP1-40 can upregulate expression of Nogo A on neuron in the high Phe condition with high level, but has no effect on normal neuron. Conclusion NEP1-40 can promote expression of Nogo A on neurons in high Phe, which facilitate the neuron grow." @default.
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- W985596590 date "2011-03-05" @default.
- W985596590 modified "2023-09-23" @default.
- W985596590 title "NEP1-40促进高苯丙氨酸损伤大鼠神经元Nogo A表达" @default.
- W985596590 hasPublicationYear "2011" @default.
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