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- W98585931 abstract "Abstract Recent reports suggest that CTLs against the conserved epitopes on HIV-1 are required for an effective HIV-1 vaccine, and that the vaccine should induce CTLs to conserved epitopes mimicking those generated by HIV-1+ long-term survivors (LTS). The CTL epitopes needed for vaccine are still unclear. Our current study identifies the evolutionarily-conserved CTL epitopes preserved between HIV-1 and FIV reverse transcriptases (RT) most frequently recognized by HIV+ subjects, including LTS. The IFNγ-ELISpot, CFSE-proliferation, and intracellular staining (ICS) analyses of PBMC upon stimulation with HIV or FIV RT peptide pools or peptides (overlapping 15-mer peptides of whole RT) were used to map the anti-FIV and anti-HIV responses made by HIV+ group (n=14 includes 7 LTS) and HIV- controls (n=5). The HIV+ subjects had HLA alleles from 8 supertypes (mainly A2 supertype) and some with B57 or B27 allele for AIDS nonprogression. Seven of 14 HIV+ subjects (includes 4 LTS) reacted to 4 FIV RT pools and to their HIV counterparts, and none by the controls. Peptides from these pools induced the proliferation of CD3+CD8+ or CD3+CD4+ T cells, which were ICS positive for IFNγ, perforin, granzyme-A, or granzyme-B in various combinations. The existence of evolutionarily-conserved CTL epitopes was determined using HIV/FIV epitope mapping. This approach can select for highly conserved epitopes that are less likely to mutate and as a result can be useful in the development of an HIV-1 vaccine." @default.
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- W98585931 date "2011-04-01" @default.
- W98585931 modified "2023-09-27" @default.
- W98585931 title "Selection of conserved HIV-1 vaccine epitopes based on cross-reactivity to feline immunodeficiency virus (53.17)" @default.
- W98585931 doi "https://doi.org/10.4049/jimmunol.186.supp.53.17" @default.
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