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- W985992941 abstract "Interleukin-23 (IL-23) and IL-17 are involved in the pathogenesis of allergic rhinitis (AR). However, the roles of IL-23 and IL-17 in ovalbumin (OVA)-induced AR remain unclear. Therefore in this study we aim to investigate the precise roles of IL-23 and IL-17 in a mouse model of OVA-induced AR. We found that during OVA-induced AR, eosinophil and goblet cells in the nose were significantly decreased in IL-23-deficient, but not in IL-17-deficient mice. However, there was no difference in the serum IgE and IgG1 levels between IL-23-deficient or IL-17-deficient and wild-type mice. Moreover, IL-4 levels in lymph node cell culture supernatants were significantly decreased in IL-23-deficient, but not IL-17-deficient, compared with wild-type mice. Furthermore, OVA-induced AR developed similarly in wild-type mice transferred with either IL-23-deficient BM cells or wild-type BM cells. These findings suggest that IL-23, but not IL-17 is crucial for the development of OVA-induced AR, and IL-23 neutralization may be a potential approach for treatment of OVA-induced AR in humans." @default.
- W985992941 created "2016-06-24" @default.
- W985992941 creator A5027435722 @default.
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- W985992941 date "2015-10-01" @default.
- W985992941 modified "2023-09-29" @default.
- W985992941 title "IL-23, rather than IL-17, is crucial for the development of ovalbumin-induced allergic rhinitis" @default.
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- W985992941 doi "https://doi.org/10.1016/j.molimm.2015.07.009" @default.
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