Matches in SemOpenAlex for { <https://semopenalex.org/work/W98673890> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W98673890 abstract "Objectives While obesity is a major risk factor for preeclampsia, which is new-onset hypertension in pregnancy, the mechanisms linking obesity and hypertension during preeclampsia are not understood. Hypertension in preeclampsia is associated with placental ischemia-induced release of factors such as anti-angiogenic sFlt-1 into the maternal circulation which antagonizes vascular endothelial growth factor (VEGF) and promotes endothelial dysfunction. The purpose of this study was to determine the effect of obesity on angiogenic factors and endothelial function in obese melanocortin 4 receptor (MC4R) knockout rats (MC4R+/−, n = 4–9) and lean control MC4R+/+ rats ( n = 4–8). Methods EchoMRI for measuring total body fat mass; carotid arterial catheters for measuring mean arterial blood pressure; ELISAs; wire myography. Results At gestational day (GD) 18, body weight (362 ± 6 vs. 336 ± 5 g) and total body fat mass (62 ± 6 vs. 45 ± 5 g) were greater ( P P P P Conclusions These data indicate that during normal pregnancy, obesity is associated with greater circulating VEGF levels and nitric oxide-dependent vasorelaxation in resistance arteries. Because soluble factors from the ischemic placental target reduce nitric oxide bioavailability, we propose that the hypertensive and endothelial dysfunction responses to reductions in uterine perfusion may be exaggerated in obese pregnant animals. Funding: HL105324, HL51971. Disclosures F.T. Spradley: None. A.C. Palei: None. J.P. Granger: None." @default.
- W98673890 created "2016-06-24" @default.
- W98673890 creator A5033919728 @default.
- W98673890 creator A5065894848 @default.
- W98673890 creator A5082451578 @default.
- W98673890 date "2015-01-01" @default.
- W98673890 modified "2023-09-24" @default.
- W98673890 title "[18-OR]" @default.
- W98673890 doi "https://doi.org/10.1016/j.preghy.2014.10.022" @default.
- W98673890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25787369" @default.
- W98673890 hasPublicationYear "2015" @default.
- W98673890 type Work @default.
- W98673890 sameAs 98673890 @default.
- W98673890 citedByCount "0" @default.
- W98673890 crossrefType "journal-article" @default.
- W98673890 hasAuthorship W98673890A5033919728 @default.
- W98673890 hasAuthorship W98673890A5065894848 @default.
- W98673890 hasAuthorship W98673890A5082451578 @default.
- W98673890 hasConcept C126322002 @default.
- W98673890 hasConcept C134018914 @default.
- W98673890 hasConcept C167734588 @default.
- W98673890 hasConcept C170493617 @default.
- W98673890 hasConcept C2776871010 @default.
- W98673890 hasConcept C2777025900 @default.
- W98673890 hasConcept C2777218350 @default.
- W98673890 hasConcept C2777583542 @default.
- W98673890 hasConcept C2779234561 @default.
- W98673890 hasConcept C2779993316 @default.
- W98673890 hasConcept C2780972559 @default.
- W98673890 hasConcept C43295716 @default.
- W98673890 hasConcept C511355011 @default.
- W98673890 hasConcept C519581460 @default.
- W98673890 hasConcept C54355233 @default.
- W98673890 hasConcept C71924100 @default.
- W98673890 hasConcept C84393581 @default.
- W98673890 hasConcept C86803240 @default.
- W98673890 hasConceptScore W98673890C126322002 @default.
- W98673890 hasConceptScore W98673890C134018914 @default.
- W98673890 hasConceptScore W98673890C167734588 @default.
- W98673890 hasConceptScore W98673890C170493617 @default.
- W98673890 hasConceptScore W98673890C2776871010 @default.
- W98673890 hasConceptScore W98673890C2777025900 @default.
- W98673890 hasConceptScore W98673890C2777218350 @default.
- W98673890 hasConceptScore W98673890C2777583542 @default.
- W98673890 hasConceptScore W98673890C2779234561 @default.
- W98673890 hasConceptScore W98673890C2779993316 @default.
- W98673890 hasConceptScore W98673890C2780972559 @default.
- W98673890 hasConceptScore W98673890C43295716 @default.
- W98673890 hasConceptScore W98673890C511355011 @default.
- W98673890 hasConceptScore W98673890C519581460 @default.
- W98673890 hasConceptScore W98673890C54355233 @default.
- W98673890 hasConceptScore W98673890C71924100 @default.
- W98673890 hasConceptScore W98673890C84393581 @default.
- W98673890 hasConceptScore W98673890C86803240 @default.
- W98673890 hasLocation W986738901 @default.
- W98673890 hasOpenAccess W98673890 @default.
- W98673890 hasPrimaryLocation W986738901 @default.
- W98673890 hasRelatedWork W2034885730 @default.
- W98673890 hasRelatedWork W2066440749 @default.
- W98673890 hasRelatedWork W2093738123 @default.
- W98673890 hasRelatedWork W2095687105 @default.
- W98673890 hasRelatedWork W2102504529 @default.
- W98673890 hasRelatedWork W2124641948 @default.
- W98673890 hasRelatedWork W2125708615 @default.
- W98673890 hasRelatedWork W2148230134 @default.
- W98673890 hasRelatedWork W2150585675 @default.
- W98673890 hasRelatedWork W2155826303 @default.
- W98673890 hasRelatedWork W2162598670 @default.
- W98673890 hasRelatedWork W2269605635 @default.
- W98673890 hasRelatedWork W2311843303 @default.
- W98673890 hasRelatedWork W2393882454 @default.
- W98673890 hasRelatedWork W2561492267 @default.
- W98673890 hasRelatedWork W2605090549 @default.
- W98673890 hasRelatedWork W2738646144 @default.
- W98673890 hasRelatedWork W2762552937 @default.
- W98673890 hasRelatedWork W2978583819 @default.
- W98673890 hasRelatedWork W2251200264 @default.
- W98673890 isParatext "false" @default.
- W98673890 isRetracted "false" @default.
- W98673890 magId "98673890" @default.
- W98673890 workType "article" @default.