FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W986804792> ?p ?o ?g. }

• W986804792 abstract "Nucleic Acids are large biomolecules and indispensable for life. They include deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Nucleic acids can adopt distinct non-canonical, highly compact secondary structure, G-quadruplex, in the dynamic region of chromosomal DNA and RNA transcripts, predominantly in telomeric sequences, and in promoter region of numerous genes including oncogenes such as Bcl-2 [1,2], VEGF [3,4], c-myc [5]. There are 376,000 putative quadruplex sequences (PQS) in the human genome that have been identified through genome-wide surveys based on a quadruplex folding rule [6], however, all of them may not exist in vivo. Recently, the existence of DNA G-quadruplex has been visualized on chromosomes in human cells [7]. These G-quadruplexes are an active target of drug discovery. The DNA G-quadruplexes formed in the promoter region of oncogene have been shown to be potential targets for anticancer drugs [8,9] and proteins. The formation of these quadruplexes in telomeres has been shown to regulate the activity of the enzyme telomerase, which maintains the length of telomeres and is involved in ~85% of all cancers. For example, Telomestatin [10,11], S2T1-6OTD (telomestatin synthetic Derivative) [12], SYUIQ-5 [13] interact with G-quadruplex formed in telomere and myc sequences and show their inhibitory activity in cancer cell growth. This has become a progressively large field of research. The G-quadruplexes are very condensed structures and formed by the ganosine (G)-rich DNA and RNA sequences and consists of several stacked G-tetrads. Each G-tetrad has four guanine arranged in a square planar arrangement and held together by hoogsteen hydrogen bonding. Besides this, each G-quadruplex structure is further stabilized by the presence of a monovalent cation, mainly potassium, which is localized in the center between each pair of tetrads. The G-quadruplexes could affect gene activity either by upregulation or down regulation, which can be achieved by inducing or stabilizing G-quadruplex formation through a G-quadruplex interacting molecule (small molecule drugs or protein) that can stabilize the G-quadruplex structure and thus perform their desired function [8]. The validation of drug-targeted G-quadruplex DNA and the modulation of cancer genes’ expression has been intensely increased in the recent past, thus opening new avenue for cancer research. Though a lot of research has been focused on DNA G-quadruplexes, there has lately been a rapid advancement in the area of RNA G-quadruplexes, chiefly in the 5 ′-UTRs (untranslated regions) of mRNAs. RNA G-quadruplexes in the 5’-UTRs of mRNAs impact posttranscriptional regulation of gene expression, which affects disruption of normal cell behavior in human diseases, particularly cancers. The recent in-vitro study on small molecule G-quadruplex binding compound that can selectively target RNA G-quadruplexes exposed a new and striking opportunity for RNA-directed drug design [14]. However, there is still a major challenge to understand the systematic effects and selectivity in in-vivo environment. It is distinct that the RNA G-quadruplex motif embodies a structurally attractive scaffold for small molecule targeting and therefore provides a productive area for future research [15]." @default.
• W986804792 created "2016-06-24" @default.
• W986804792 creator A5018902992 @default.
• W986804792 date "2015-01-01" @default.
• W986804792 modified "2023-09-30" @default.
• W986804792 title "Recent Advances in Anticancer Drugs Development: G-Quadruplex as New Drug Target" @default.
• W986804792 cites W1969583921 @default.
• W986804792 cites W1991590162 @default.
• W986804792 cites W2010706687 @default.
• W986804792 cites W2020374412 @default.
• W986804792 cites W2041919391 @default.
• W986804792 cites W2044279725 @default.
• W986804792 cites W2056581209 @default.
• W986804792 cites W2059306569 @default.
• W986804792 cites W2097521277 @default.
• W986804792 cites W2109139793 @default.
• W986804792 cites W2129522390 @default.
• W986804792 cites W2154033106 @default.
• W986804792 cites W2155773930 @default.
• W986804792 cites W2167223269 @default.
• W986804792 cites W2169745877 @default.
• W986804792 cites W2171706918 @default.
• W986804792 cites W2171830519 @default.
• W986804792 cites W2278005102 @default.
• W986804792 doi "https://doi.org/10.4172/2329-6887.1000e134" @default.
• W986804792 hasPublicationYear "2015" @default.
• W986804792 type Work @default.
• W986804792 sameAs 986804792 @default.
• W986804792 citedByCount "5" @default.
• W986804792 countsByYear W9868047922015 @default.
• W986804792 countsByYear W9868047922016 @default.
• W986804792 countsByYear W9868047922017 @default.
• W986804792 countsByYear W9868047922019 @default.
• W986804792 crossrefType "journal-article" @default.
• W986804792 hasAuthorship W986804792A5018902992 @default.
• W986804792 hasBestOaLocation W9868047921 @default.
• W986804792 hasConcept C2780035454 @default.
• W986804792 hasConcept C3018146709 @default.
• W986804792 hasConcept C556039675 @default.
• W986804792 hasConcept C64903051 @default.
• W986804792 hasConcept C70721500 @default.
• W986804792 hasConcept C71924100 @default.
• W986804792 hasConcept C86803240 @default.
• W986804792 hasConcept C98274493 @default.
• W986804792 hasConceptScore W986804792C2780035454 @default.
• W986804792 hasConceptScore W986804792C3018146709 @default.
• W986804792 hasConceptScore W986804792C556039675 @default.
• W986804792 hasConceptScore W986804792C64903051 @default.
• W986804792 hasConceptScore W986804792C70721500 @default.
• W986804792 hasConceptScore W986804792C71924100 @default.
• W986804792 hasConceptScore W986804792C86803240 @default.
• W986804792 hasConceptScore W986804792C98274493 @default.
• W986804792 hasIssue "02" @default.
• W986804792 hasLocation W9868047921 @default.
• W986804792 hasOpenAccess W986804792 @default.
• W986804792 hasPrimaryLocation W9868047921 @default.
• W986804792 hasRelatedWork W1603416295 @default.
• W986804792 hasRelatedWork W1959407146 @default.
• W986804792 hasRelatedWork W1988861809 @default.
• W986804792 hasRelatedWork W2078153320 @default.
• W986804792 hasRelatedWork W2080081537 @default.
• W986804792 hasRelatedWork W2097742807 @default.
• W986804792 hasRelatedWork W2160241155 @default.
• W986804792 hasRelatedWork W2329258414 @default.
• W986804792 hasRelatedWork W2464000729 @default.
• W986804792 hasRelatedWork W3202735287 @default.
• W986804792 hasVolume "03" @default.
• W986804792 isParatext "false" @default.
• W986804792 isRetracted "false" @default.
• W986804792 magId "986804792" @default.
• W986804792 workType "article" @default.