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- W987445747 abstract "A major argument in favor of local defects in the host defense against staphylococcal foreign-body infections was obtained by studies performed with experimentally infected animals. Effective protection from foreign-body infection was indeed obtained by injection of fresh neutrophils into tissue cages. In vitro studies aiming to describe mechanisms of bacterial attachment relevant to the colonization of indwelling devices are frequently performed in the absence of any hostrelevant factors. A section of this chapter emphasizes the critical role of host proteins, whether surface-bound or in the fluid phase, in modulating staphylococcal attachment to artificial implants. More recent studies using specific adhesin-defective mutants of Staphylococcus aureus confirmed the role of fibronectin in promoting bacterial attachment to subcutaneously implanted coverslips. The high susceptibility of patients with indwelling devices to microbial infections results from important defects in the cytokine and phagocytic-bactericidal responses. Experimental models have documented these defects in the vicinity of subcutaneously implanted tissue cages locally challenged with S. aureus or S. epidermidis. Such implanted tissue cages or coverslips were found to be progressively colonized by host-derived humoral and cellular elements. A number of approaches may be considered for reducing host susceptibility to foreign-body infections. An improved understanding of molecular and physiological mechanisms of phenotypic antibiotic tolerance of implant-associated organisms might bring new clues to more effective treatment strategies." @default.
- W987445747 created "2016-06-24" @default.
- W987445747 creator A5001893799 @default.
- W987445747 creator A5010055797 @default.
- W987445747 creator A5063814087 @default.
- W987445747 creator A5069420480 @default.
- W987445747 date "2014-04-30" @default.
- W987445747 modified "2023-09-24" @default.
- W987445747 title "Host Factors Predisposing to and Influencing Therapy of Foreign Body Infections" @default.
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